Institute of Ophthalmology Affiliated To Shandong First Medical University (shandong Institute of Ophthalmology, Qingdao Eye Hospital Affiliated To Shandong First Medical University)

Institute of Ophthalmology Affiliated To Shandong First Medical University (shandong Institute of Ophthalmo

Hongwei Wang

Qingjun Zhou

Weiyun Shi

Bining Zhang

Fangying Song

In view of the problem that the current prevention and treatment manners for corneal neovascularization (CNV) may cause complications, the present disclosure provides an application of CB-839 in preparation of a drug for inhibiting CNV. The CB-839-loaded drug of the present disclosure can significantly inhibit CNV in mice and reduce the infiltration of inflammatory cells without obvious side effects, which makes up for the shortcoming of the prior art.

Application of CB-839 in preparation of drug for inhibiting corneal neovascularization (CNV)

A preparation method of a nanozyme composite-based hybrid hydrogel eye drop includes synthesizing a tannin-coordinated silver/cobalt composite nanoparticle through a coordination reaction of cobalt chloride hexahydrate with ammonia water and an oxidation-reduction reaction of silver nitrate with tannin; and mixing the silver/cobalt composite nanoparticle with an acrylate-modified gelatin, conducting an ultrasonic treatment to allow complete dissolution, and irradiating a resulting mixture under ultraviolet (UV) light to obtain the nanozyme composite-based hybrid hydrogel eye drop. The preparation method of the present disclosure has simple operations and a short preparation time. The eye drop prepared by the preparation method shows a broad-spectrum bactericidal effect against a variety of bacteria and fungi, and has prominent preventive and therapeutic effects for bacterial and drug-resistant bacterial corneal infections.

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Qingdao, China

Hongwei Wang