Jiangsu Micromedmark Biotech Co., Ltd.

Hongwei Liang

Chenyu Zhang

Xi Chen

Ke Zeng

Uzair Ur-Rehman

Junfeng Zhang

Zhen Zhou

Provided are an EGFR gene expression-suppressing siRNA, a precursor sequence of same, and uses thereof.

EGFR gene expression-suppressing siRNA, precursor of same, and applications thereof

The present invention discloses an siRNA that inhibits K-RAS gene expression, and the precursor sequences and applications thereof. The K-RAS siRNA and its precursor sequences provided by the present invention can efficiently inhibit the expression of the K-RAS gene, and in vivo experiments have shown that the K-RAS siRNA has a certain inhibitory effect on tumours highly expressing K-RAS. The precursor of the siRNA of the invention and its vector can form a stable siRNA that functions in a host.

K-RAS gene expression-suppressing siRNA, precursor of same, and applications thereof

Provided are a new precursor miRNA and the applications in tumor therapy thereof. The precursor miRNA, from 5'- to 3&#x2032;-end thereof, has the structure represented by formula (I). B1 is an anti-miRNA and/or siRNA to be expressed; B2 is a sequence substantially or completely complementary to B1, and B2 is not complementary to C; C is a sequence with stem-loop structure; A1 and A2 are independently hydrogen or optionally a RNA sequence consisting of 4 to 5 bases. The precursor miRNA can be processed to form an anti-miRNA and/or siRNA in hosts. 

Precursor miRNA and applications in tumor therapy thereof

Provided are a method and use of microRNA MiR-2911 in regulating an ebola virus. Particularly provided are a method and use of isolated microRNA MiR-2911 in regulating an ebola virus protein gene.

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Jiangsu, China

Hongwei Liang