Nanyang Technological University

National University of Singapore

Hongwei Duan

Bee Eng Mary Chan

Liang Yang

Yu Du

Xuewei Liu

Chun Yee Lim

Qirong Xiong

Kaixi Zhang

Zhangyong Si

Jiajing Zhou

Rubi Zamudio Vazquez

Ling Bai

Yuguang Mu

Yee Cheong Lam

Jingxi He

Kim Le Mai Hoang

The invention relates to a compound of formula Ia and/or formula Ib: or a pharmaceutically acceptable salt, solvate or prodrug thereof, where the groups are defined herein. The invention also relates to a pharmaceutical formulation comprising the compound for treating or detecting a microbial infection in a subject, a method of determining antimicrobial resistance of a microbial infection using the compound, and a method of determining an effective dose of one or more antimicrobial agents to kill a microorganism using the compound.

Biohybrid peptidoglycan oligomers

There is provided a β-peptido sugar-copolymer having the structure of formula (I) as defined herein, or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of the same. There is provided a process to make the β-peptido sugar-copolymer as defined herein. There are further provided medical applications of the β-peptido sugar-copolymer as defined herein. In a preferred embodiment, a block-like copolymer poly(amido-D-glucose)-block-poly-β-(L)-homolysine (PDGu-b-PBLK) synthesized via anionic ring-opening polymerization (ROP) demonstrates an antimicrobial efficacy, an enhanced selectivity towards different bacteria, biocompatibility vs. mammalian cells and spontaneous assembly.

Beta-peptido sugar-copolymer

A method for preparing a magnetic chain structure is provided. The method comprises providing a plurality of magnetic particles; dispersing the plurality of magnetic particles in a solution comprising a dopamine-based material to form a reaction mixture; applying a magnetic field across the reaction mixture to align the magnetic particles in the reaction mixture; and polymerizing the dopamine-based material on the aligned magnetic particles to obtain the magnetic chain structure. A magnetic chain structure prepared by the method is also provided.

Method for preparing a magnetic chain structure

According to the present disclosure, an isotropic structural colour printing process is provided. The process comprising (a) providing an ink composition comprising ink particles (such as polymeric particles (e.g. polystyrene), metal-organic frameworks (MOFs) (e.g. ZIF-8)) in a liquid reagent; and (b) depositing the ink composition onto a surface of a substrate (e.g. anodic aluminium oxide membrane, photo papers). Due to capillary action and/or absorption of the liquid reagent, the ink particles form an amorphous arrangement of structures that lead to isotropic structural colour. In the preferred embodiment, the ink particles may further be coated with a catechol group (such as polydopamine). An apparatus for detecting a target substance in the gaseous phase, wherein the apparatus comprises a nanostructure capable of exhibiting a change in isotropic structural colour when one or more molecules of the target substance are entrapped as an indication that the target substance is present, is also provided.

Process for isotropic structural colour printing and an apparatus for detecting a target substance in the gaseous phase

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Singapore, Singapore

Hongwei Duan