Tianjin Chase Sun Pharmaceutical Co., Ltd

The First Affiliated Hospital, Third Military Medical University, Pla

The First Affiliated Hospital, Third Military University, Pla

The First Affiliated Hospital, Third Military Medical Universty, Pla

Hongwei Cao

Hong Qing Zhou

Jiang Zheng

Xin Liu

Xinchuan Zheng

Ning Wang

Yongling Lu

Min Huang

Yan Li

Yang Yang

Yuanfeng Zhu

Guo Wei

Jingcheng Yang

Kecen Zhao

The use of Kukoamine A and Kukoamine B in the preparation of drugs for the prevention and treatment of sepsis and autoimmune disease is disclosed. Bacterial endotoxin/lipopolysaccaride (LPS) and unmethylated DNA (CpG DNA) of bacteria, the major pathogen-associated molecular patterns in sepsis and autoimmune disease, are specifically targeted, while the disclosed use directionally isolates lead compounds from traditional Chinese medicine. These measures can overcome the major defects of uncertainty of pharmacological material basis and drug targets of extracts and constituents of traditional Chinese medicine. The disclosed use can help in developing a safe, effective and quality controllable drug for prevention and treatment of sepsis and autoimmune disease so as to help solve the present lack of effective drugs in clinical treatment.

Use of kukoamine A and kukoamine B

Salts of kukoamine B, their preparation method and their pharmaceutical use in preparation of drugs for preventing and treating sepsis. Experiments indicate that salts of kukoamine B have a good effect on antagonizing the key factors inducing sepsis, and can be used in the preparation of drugs for preventing and treating sepsis. Under the current circumstances of the lack of effective measures for the treatment of sepsis in clinical practice, the medicinal formulations, which comprise the salts of kukoamine B, pharmaceutically acceptable carrier and/or diluent, provide a new approach for the prevention and treatment of sepsis.

Salts of kukoamine B, preparation method and use thereof

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Chongqing, China

Hongwei Cao