Hoffmann-la Roche Inc.

Shanghai Simgui Technology Co., Ltd.

F. Hoffmann-la Roche Ag

Hongtao Xu

Wei Zhu

Ge Zou

Fabian Dey

Hong Shen

Hongying Yun

Weixing Zhang

Xing Wei

Dongdong Chen

Zhisen Zhang

Meng Chen

Jianguo Chen

Zongxing Qiu

Nan Gao

Xin Su

Dong Ding

The present invention relates to compounds of formula (I), wherein Rto Rand n are as described herein, and their pharmaceutically acceptable salt thereof, and compositions including the compounds and methods of using the compounds.

Hydro-1H-pyrrolo[1,2-a]pyrazine compounds for the treatment of autoimmune disease

The present invention relates to compounds of formula (I), wherein Rand Rand n are as described herein, and their pharmaceutically acceptable salt thereof, and compositions including the compounds and methods of using the compounds.

Hydropyrazino[1,2-d][1,4]diazepine compounds for the treatment of autoimmune disease

The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts thereof. The compounds act as antagonists of the toll-like receptors TLR7, TLR8 and/or TLR9 and are thus useful in the treatment of systemic lupus erythematosus (SLE) and lupus nephritis.

Hydropyrido[1,2-α]pyrazine compounds for the treatment of autoimmune disease

The present invention relates to compounds of formula (I), wherein Rto R, m and n are I a described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.

Tetrahydro-1H-pyrazino[2,1-a]isoindolylquinoline compounds for the treatment of autoimmune disease

The present invention relates to compounds of formula (I), wherein R, Rand Rare as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds as antagonist of TLR7 and/or TLR8 and/or TLR9 in the treatment of autoimmune diseases as well as auto-inflammation diseases. 

Cyclic amidine compounds for the treatment of autoimmune disease

The present disclosure provides a bonding method for a semiconductor substrate, which may improve flatness of a bonded substrate. The present disclosure further provides a bonded semiconductor substrate. The semiconductor substrate is thermally treated prior to bonding, and oxygen precipitates in the semiconductor substrate are partially or totally converted to interstitial oxygen atoms in the thermal treatment.

Bonding method for semiconductor substrate, and bonded semiconductor substrate

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Shanghai, China

Hongtao Xu