Johns Hopkins University

Kala Pharmaceuticals, Inc.

Centocor Ortho Biotech Inc.

Transform Pharmaceuticals, Inc.

Hongming Chen

Elizabeth M Enlow

Alexey Popov

James Bourassa

Justin Scot Hanes

Samuel K Lai

Laura M Ensign

Ming Yang

Colin R Gardner

Tao Yu

Winston Zapanta Ong

Pawel Wojciech Nowak

Jinsoo Kim

Yen Cu

Orn Almarsson

Zhong Zhang

Julius F Remenar

Matthew Lynn Peterson

Mark Tawa

Mark Oliveira

Hector Guzman

Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.

Nanocrystals, compositions, and methods that aid particle transport in mucus

Particles, compositions, and methods that aid particle transport in mucus are provided. The particles, compositions, and methods may be used, in some instances, for ophthalmic and/or other applications. In some embodiments, the compositions and methods may involve modifying the surface coatings of particles, such as particles of pharmaceutical agents that have a low aqueous solubility. Such compositions and methods can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for ophthalmic applications, and may be used for delivering pharmaceutical agents to the front of the eye and/or the back of the eye.

Compositions and methods for ophthalmic and/or other applications

The present invention provides novel derivative of &#x3b2;-lactam antibiotics, such as meropenem. The inventive compounds include compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof. Also provided are particles (e.g., nanoparticles) and pharmaceutical compositions thereof that are mucus penetrating. The inventive particles and pharmaceutical compositions may be useful in delivering an inventive compound to the respiratory tract of a subject. The invention further provides methods of using and kits including the inventive compounds, particles thereof, and/or pharmaceutical compositions thereof for treating and/or preventing a pulmonary disease (e.g., a respiratory tract infection). 

Meropenem derivatives and uses thereof

Growing community of inventors

Belmont, MA, United States of America

Hongming Chen