Genentech, Inc.

Gilead Connecticut, Inc.

University of Utah Research Foundation

University of Tennessee Research Foundation

Honglu Zhang

Kevin S Currie

Scott A Mitchell

Peter A Blomgren

Jeffrey E Kropf

Jianjun Xu

Seung H Lee

Xiaojing Wang

Zhongdong Zhao

Daniel Fred Ortwine

Wendy B Young

Aaron C Schmitt

Pavel E Zhichkin

Antonio J M Barbosa

Ravi Krishnamoorthy

Glenn D Prestwich

Guanghui Yang

Gabor G Tigyi

Antonio J Barbosa

Xiaoyu Xu

Joanna Gajewiak

Guowei Jiang

Pyridone and aza-pyridone compounds of Formula I are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed. 

Pyridone and aza-pyridone compounds and methods of use

Described herein is the synthesis and pharmacology of a series of &#x3b1;-substituted methylene phosphonate analogs, in which the &#x3b1;-CHmoiety is replaced with CHCl or CHBr.

Alpha-chloro and alpha-bromo phosphonate analogs of lysophosphatidic acid and methods of making and using thereof

Growing community of inventors

Guilderland, NY, United States of America

Honglu Zhang