Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Suzhou Botany Biomedical Co., Ltd.

Suzhou Botany Biomedicals Co., Ltd

Honglin Wang

Jian Li

Shuhui Chen

Guoping Hu

Shilan Liu

Dahai Wang

Guibai Liang

The present application relates to a crystal of a tricyclic compound, in particular to a crystal of (S)-8-(4,4-difluorocyclohexyl)-8H-thieno[3,4]pyrrolo[1,5-a]imidazole, a preparation method therefor, a crystal composition and a pharmaceutical composition thereof and the use thereof. The X-ray powder diffraction spectrum of the crystal of the compound of formula I in the present application, represented by a 2&#x3b8; value, has a diffraction peak at about 11.49&#xb0;, 15.05&#xb0;, 20.14&#xb0;, 21.53&#xb0; or 21.79&#xb0;. The crystal of the compound of formula I in the present application has excellent physical properties, high safety and metabolic stability, and has a good inhibitory effect on IDO and a high medicinal value.

Crystal of tricyclic compound

The present invention relates to new pentacyclic triterpenes, their preparation method and use. The compounds of the present invention could effectively treat psoriasis and selectively inhibit in vitro differentiation of the T1 and T17 cells, thereby could be used to treat the T1- or T17-mediated autoimmune diseases.

Pentacyclic triterpenoid compound with modified structure and preparation method and use thereof

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Shanghai, China

Honglin Wang