Shanghai United Imaging Healthcare Co., Ltd.

Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Merck Sharp + Dohme Corp.

Ocumension Therapeutics (suzhou) Co., Ltd.

Hongjian Wang

Jieyan Ma

Shilan Liu

Shuhui Chen

Joseph A Kozlowski

Ming Zhang

Hao Wu

Wensheng Yu

Younong Yu

Jian Liu

Ronald M Kim

Ying-Duo Gao

Rajan Anand

Xiaolei Gao

Wenyuan Qian

Yuan Ren

Fei Liu

Chundao Yang

Sobhana Babu Boga

Oleg B Selyutin

Deodialsingh Guiadeen

Guibai Liang

Yanlong Liu

Zhongyuan Hu

Huihui Zhang

Liang Tan

Yahui Guo

Lei Xing

Provided is a salt of an Syk inhibitor and a crystalline form thereof, and more specifically, provided are 5-fluoro-1-methyl-3-((5-(4-(oxetan-3-yl)piperazine-1)-yl)pyridin-2-yl)amino)-6-(1H-pyrazol-3-yl)quinoline-2(1H)-ketamine hydrochloride, a crystalline form thereof, a preparation method therefor, a pharmaceutical composition thereof and a use thereof. The hydrochloride of the compound represented by formula I and the crystalline form thereof have good salt-forming properties, high stability and low hygroscopicity, have advantages in terms of physical properties, safety and metabolic stability, and have value in prepared medicines.

Salt of Syk inhibitor and crystalline form thereof

The present application relates to a method for acquiring maximum principal strain or a maximum principal stress status of a vessel wall. The method includes: acquiring first vessel data of a first time phase corresponding to a vessel; acquiring second vessel data of a second time phase corresponding to the vessel; generating, based on the first vessel data, a first vessel model relating to the first time phase, generating a second vessel model relating to the second time phase based on the second vessel data; determining a region of interest in the first vessel model; determining the corresponding region of interest in the second vessel model; determining a reference point in the region of interest of the first vessel model; determining the corresponding reference point in the region of interest of the second vessel model; determining a displacement of the reference point from the first vessel model to the second vessel model; and determining a maximum principal strain or a maximum principal stress at the reference point based on the displacement of the reference point.

Method and system for acquiring status of strain and stress of a vessel wall

Provided are a Syk inhibitor and a use method therefor, and in particular, disclosed are quinolinone represented by formula (I) or quinazoline derivatives or pharmaceutically acceptable salts thereof, a preparation method, a pharmaceutical composition, and uses in preparing a medicament for treatment of Syk receptor related diseases. 

Syk inhibitor and use method therefor

The present application relates to a method and system for analyzing blood flow conditions. The method includes: obtaining images at multiple time phases; constructing multiple vascular models corresponding to the multiple time phases; correlating the multiple vascular models; setting boundary conditions of the multiple vascular models respectively based on the result of correlation; and determining condition of blood vessel of the vascular models.

Systems and methods for analysis of blood flow state

Method and system for analyzing blood flow condition

The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds in the treatment of Btk mediated disorders. 

Substituted benzamides and substituted pyridinecarboxamides as Btk inhibitors

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Shanghai, China

Hongjian Wang