Yangtze River Pharmaceutical Group Co., Ltd.

Chinese Academy of Sciences

China Pharmaceutical University

Hongguo Lu

Tianjiang Sun

Ting Guo

Yungen Xu

Min Chen

Dechuan Wang

Jinggen Liu

Xiaohong Gu

A kind of tetrahydro isoquinoline derivatives (I), their preparation methods, medicine compositions and medicinal uses thereof, especially their uses as &#x3ba;-opioid receptor excitant in pain relieving, which belongs to the medicine chemistry. The substituents R, R, R, Rof general formula (I) are defined as the description. 

Tetrahydro isoquinoline derivatives, preparation methods and medicinal uses thereof

The present invention discloses an oral preparation of dyclonine hydrochloride for the endoscopic examination in upper gastrointestinal tract, which has the effects of anesthetization and lubrication, and an oral preparation comprising dyclonine hydrochloride that has the advantages of avoiding foam in the body cavity, preventing vomiting, and offering a clear view. The preparation of the present invention comprises, as main ingredients, 0.2%-3% weight percent of dyclonine hydrochloride, 1%-12% weight percent of polyvinyl alcohol, 1%-10% volume percent of glycerin, 1%-10% volume percent of a defoaming agent, and a balance of a pharmaceutically acceptable adjuvant. The viscosity of the preparation is in a range of 30 to 300 mpa&#xb7;s and the pH value is in a range of 2.0 to 8.0.

Oral preparation of dyclonine hydrochloride

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Taizhou, China

Hongguo Lu