Brock University

National Research Council of Canada

Hongbin Yan

Wangxue Chen

Rhonda Kuo Lee

Kha Tram

Disclosed is the use of fluorinated cyclic dinucleotides and pharmaceutically acceptable salts thereof as an adjuvant for the preparation of an oral vaccine. Further disclosed is the use of fluorinated cyclic dinucleotides and pharmaceutically acceptable salts thereof for enhancing the immune response to an orally administered vaccine.

Use of fluorinated cyclic dinucleotides as oral vaccine adjuvants

The present application is directed to compounds of Formula I: wherein R-R, X, Y and Z are as defined in the application, and to the use of the compounds of Formula I, for example, for the fluorescent labeling of oligonucleotides.

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St. Catharines, Canada

Hongbin Yan