Senomyx, Inc.

Cytovia, Inc.

Dow Agrosciences LLC

Biolegend, Inc.

Sorrento Therapeutics, Inc.

Corteva Agriscience LLC

Shire Biochem, Inc.

Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.

Firmenich Incorporated

Myrexis, Inc.

Myriad Pharmaceuticals, Inc.

Ionis Pharmaceuticals, Inc.

Akzo Nobel Chemicals International B.v.

Hong Zhang

Sui Xiong Cai

Donald Karanewsky

Catherine Tachdjian

Guy Servant

Qing Chen

Xiaodong Li

Vincent Darmohusodo

Feng Zhang

Mei Li

Holger Tank

Lei Liu

Hui Shao

Stephen L Wilson

Kuide Qin

Timothy Davis

Gang Chen

Tong Zhu

Songchun Jiang

Zhenwei Miao

John A Drewe

David George Ouse

Han-Zhong Zhang

Xiao-Qing Tang

Joseph R Fotsing

Albert Zlotnik

Richard Masten Fine

Boris Klebansky

Sara L Adamski-Werner

Marketa Rinnova

Benoit Pelletier

Susan M Freier

Brett P Monia

Fengjun Xi

Mark Zoller

Jingyi Wang

Lichun Wang

Andrew M Siwkowski

Shawn Zhu

Yufeng Hong

Jing Wang

James Michael Gifford

William E Kemnitzer

Victor Selchau

Melissa Sue Wong

John Ransom

Xiao Qing Tang

Brandon Matthew Downer

Dhanesh Gohel

Alisher B Khasanov

Goran Petrovic

Joseph C Hercamp

Hao Shen

Richard Storer

Nilantha Sudath Sirisoma

Jeffrey Robert Hammaker

Jared Kuemmerle

Haitian Liu

Xinshan Kang

Rachel D A Kimmich

Jeffrey Yamamoto

Shailaja Kasibhatla

Giorgio Attardo

Tongtong Xue

Hongmei Song

Mark B Anderson

Liang Xiao

Hong Zeng

Brant Clayton Boren

Jeffrey R Crosby

Jinxia Susan Sun

Real Denis

Chenguang Zhao

Azra Pervin

Brett Weylan Ching

Charlie James Flood

Min Zhao

Franklin Nelson Keeney

Alexander Wilhelm Chucholowski

Stephen Craig Bennett

Bhupinder Baath

Carlton Stephen Seckinger

Adam Willardsen

Emma Louise Hawkins

Alex Kennedy

Kazuyuki Suzuki

F Nelson Keeney

Melissa S Wong

Liping Liu

Binh Vong

Yan Qing

Stephanie Lapera

Chris Pleiman

Marco Antonio Tavares Do Nascimento

Qiuyan Yang

Li Yin

Dylan Dalun Deng

James M Gifford

Processes and compositions are described for preparing new, colloidally stable, coated nanomagnetic particles useful for both in-vitro and in-vivo biomedical applications, including cell targeting and capturing cells, microorganisms, and cellular organelles or entities such as exosomes. These nanomagnetic particles can also be used as imaging contrast agents due to their small size and high magnetic moment. The nanomagnetic particles include a series of sequentially added, stabilizing surface coatings rendered onto nano-sized magnetic crystal clusters (e.g., magnetite particles) to impart colloidal stability in complex biological samples with minimal leaching of the coating materials, high binding capacity, and low non-specific binding. Another benefit of this invention is the ability to utilize both external and internal magnetic field-generating separation devices to effect separation of the magnetic nanoparticles.

Stable nanomagnetic particle dispersions

Spray drift during the application of an aqueous mixture of glyphosate and an auxinic herbicide is reduced by incorporating certain tertiary amine or tertiary amine oxide surfactants into the aqueous solution or mixture to be sprayed.

Amine and amine oxide surfactants for controlling herbicide spray drift

Provided is a preparation method of an antibody-drug conjugate represented by Formula (I), or a pharmaceutically acceptable salt or stereoisomer thereof, or a solvate of the foregoing,

Anti-ErbB2 antibody-drug conjugate and composition thereof, preparation method therefor, and use thereof

The methods of the invention employ targeted magnetic particles, preferably targeted nanomagnetic particles, and targeted buoyant particles such as buoyant microparticles and microbubbles. Among the benefits of the invention is the ability to combine targeted magnetic particles with differentially targeted buoyant particles to achieve separation of two or more specifically cell targeted populations during the same work flow.

Compositions and methods for performing magnetibuoyant separations

Disclosed herein are 4-amino-5-(cyclohexyloxy)quinoline-3-carboxylic acid compounds having useful as sweet flavor modifiers. Also disclosed herein are ingestible compositions that include one or more of these compounds in combination with a natural or artificial sweetener.

Substituted 4-amino-5-(cyclohexyloxy)quinoline-3-carboxylic acids as sweet flavor modifiers

Novel high-strength herbicidal oil-in-water emulsions containing a water soluble salt of glyphosate and an oil soluble herbicide active ingredient show enhanced stability to oil phase coalescence and active ingredient crystallization by the use of specific surfactants and water immiscible organic solvents.

Stable high strength oil-in-water emulsions

There is disclosed derivatives of amanitin conjugated to a targeting antibody to form an ADC (antibody drug conjugate).

Antibody drug conjugates having derivatives of amatoxin as the drug

There is disclosed an improved ADC (antibody drug conjugate) type composition having at least two different drug payloads conjugated to a single targeting protein. More specifically, the present disclosure attaches a first drug conjugate to a dual Cysteine residue on a targeting protein and a second drug conjugate with a different drug to a Lys residue on the targeting protein.

Drug-conjugates with a targeting molecule and two different drugs

There is disclosed a Dolastatin derivative, conjugated to an antibody, comprising a Dolastatin derivative moiety of Formula IV.

Antibody drug conjugates

The present invention includes compounds having structural formula (I), or pharmaceutically acceptable salts, solvate, and/or ester thereof. These compounds are useful as sweet flavor modifiers. The present invention also includes compositions comprising the present compounds and methods of enhancing the sweet taste of ingestible compositions. Furthermore, the present invention provides methods for preparing the compounds.

Sweet flavor modifier

The present invention includes compounds having structural formula (I), or salts or solvates thereof. These compounds are useful as sweet flavor modifiers. The present invention also includes compositions comprising the present compounds and methods of enhancing the sweet taste of compositions.

The mixture of potassium or certain amine salts of glyphosate and dicamba allows the preparation of high-strength liquid compositions containing greater than 300 gae/L of total active ingredient loading if the pH is adjusted between about 6.0 and about 8.0. Compositions are particularly well-suited for herbicidal applications on crops that are resistant or tolerant to both glyphosate and dicamba.

Herbicidal concentrate compositions containing glyphosate and dicamba salts

Growing community of inventors

San Diego, CA, United States of America

Hong Zhang