Novartis Ag

Hong-Yong Kim

Mahavir Prashad

Prasad Koteswara Kapa

Michael Mutz

Andrew James Culshaw

Yugang Liu

Michael John Girgis

Bin Hu

Jessica Liang

Peter Gull

Joel Slade

Max Peter Seiler

Kaspar Zimmermann

Weichun Chen

Allan Hallett

Ruoqiu Wu

Christopher Towler

There is described a new polymorphic form of 4-(7-Hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile and a method of preparing it.

Quinazolinone derivatives useful as vanilloid antagonists

The invention provides compounds of formula (I) wherein R, R, R, R, and Rare as defined in the description, and the preparation thereof. The compounds of formula (I) are useful as pharmaceuticals. 

Fused pyridine derivatives for use as vanilloid receptor antagonists for treating pain

Improved processes for preparing intermediates useful for preparing antibacterial N-[1-oxo-2-alkyl-3-(N-hydroxyformamido)-propyl}-(carbonylamino-aryl or -heteroaryl)-azacyclo4-7alkanes or thiazacyclo4-7alkanes, which have one or more of the following features: (1) make use of a particular &#x3b2;-lactam intermediate; (2) which make use of a particular resolving agents, enantiomerically pure substituted propionic acids, especially (R)-2-butyl-3-hydroxy-propionic acid; (3) which avoid the use of hydrogen peroxide; and (4) which facilitate selective debenzylation reducing production of waste by-products.

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Whippany, NJ, United States of America

Hong-Yong Kim