University of Washington

Coopervision International Holding Company, LP

Coopervision International Limited

Hong Xue

Shaoyi Jiang

Shengfu Chen

Louisa Ruth Carr

Yuwen Liu

Yuting Li

Gang Cheng

Andrew Keefe

Charlie Chen

Zheng Zhang

Yuan Xu

Wei Yang

Arthur Back

Paul Richardson

Ying Zheng

Junhao Ge

Hiroyuki Ueyama

Charles A Francis

Victoria Rogers

Peter P Zhu

Andrew Luk

Guigui Wang

Norman David Brault, Jr

Ying Ye

Yun Zhang

Peter Chaoquan Zhu

Xuewei Xu

Changlu Gao

Guozhu Li

Shane Mao

Xining Zhang

Luo Mi

Zhiqiang Cao

Lei Zhang

Methods are disclosed for manufacturing a coated contact lens that comprises a polymeric lens body comprising an acid group, a first coating polymer comprising a first amine group ionically bound to the acid group, and a second coating bound to the first coating polymer through covalent linkage between a nitrogen atom of a second amine group on the first coating polymer and an amine-reactive group of the second coating polymer. In some examples the lenses exhibit improved surface properties compared to uncoated lenses, such as reduced adhesion, increased wettability, increased lubricity, and/or increased lipid resistance.

Methods of manufacturing coated contact lenses

Marine coatings including cationic polymers hydrolyzable to nonfouling zwitterionic polymers, coated marine surfaces, and methods for making and using the marine coatings.

Marine coatings

Zwitterionic polymer and mixed charge copolymer bioconjugates, methods for making and using the bioconjugates.

Zwitterionic polymer bioconjugates and related methods

Zwitterionic crosslinking agents, crosslinked zwitterionic hydrogels prepared from copolymerization of zwitterionic monomers with the zwitterionic crosslinking agent, methods for making crosslinked zwitterionic hydrogels, and devices that include and methods that use the crosslinked zwitterionic hydrogels.

Crosslinked mixed charge hydrogels

HEMA-compatible siloxane monomers are described that can be used to manufacture contact lenses that combine the attributes of HEMA-based contact lenses with the high oxygen permeability of silicone hydrogel lenses. Optically clear silicone hydrogel contact lens can be manufactured that comprise a polymeric lens body that is the reaction product of a polymerizable composition comprising: a) at least 25 wt. % of at least one hydroxyalkyl methacrylate; and b) at least 20 wt. % of at least one HEMA-compatible polysiloxane.

Contact lenses made with HEMA-compatible polysiloxane macromers

Silicone hydrogel contact lenses comprising an ionic component sustain release of beneficial cationic polymers.

Silicone hydrogel contact lenses for sustained release of beneficial polymers

Miscible polymerizable compositions comprising at least one primary amine-containing methacrylate monomer, or at least one primary amine-containing methacrylamide monomer, in addition to 20-80 wt. % siloxane monomer, 20-80 wt. % hydrophilic monomer, cross-linking agent, and polymerization initiator, are described. These polymerizable compositions can be used to form silicone hydrogel contact lenses, and in methods of manufacturing silicone hydrogel contact lenses.

Primary amine-containing silicone hydrogel contact lenses and related compositions and methods

Crosslinked zwitterionic hydrogels

Zwitterionic polymers having adhesive groups, methods for making the polymers, surfaces having the polymers grafted thereto and grafted therefrom, and methods for making and using the polymer-modified surfaces.

Zwitterionic polymers having biomimetic adhesive linkages

A method for preparing a polymerizable monomer-dye compound is provided in which a monomer, a reactive dye, and base are combined under substantially anhydrous reaction conditions to form the polymerizable monomer-dye compound, wherein the monomer comprises a pendant reactive group that covalently links to the reactive dye to form the monomer-dye compound.

Reactive dyes for contact lenses

Cationic polymers hydrolyzable to zwitterionic polymers, monomers for making the cationic polymers, surfaces that include the polymers, and methods for making and using the cationic polymers and surfaces. The cationic polymers include counterions and/or hydrolyzable groups that release active agents.

Integrated antimicrobial and low fouling materials

Zwitterionic block copolymers and zwitterionic conjugates that advantageously self-assemble into particles, particles assembled from the zwitterionic block copolymers and zwitterionic conjugates, pharmaceutical compositions that include the self-assembled particles, and methods for delivering therapeutic and diagnostic agents using the particles.

Self-assembled particles from zwitterionic polymers and related methods

Growing community of inventors

Pleasanton, CA, United States of America

Hong Xue