Immunomet Therapeutics Inc.

Lucky Limited

Hong Woo Kim

Ji Sun Lee

Sung Wuk Kim

Hye Jin Heo

Hong Bum Lee

Ji Ae Kook

Young Woo Lee

Jae Kap Jeong

Sang Hee Yoo

Jeong Soo Kim

Jin H Cho

Su M Hong

Sang H Chae

Ji Hyun Park

Young Hee Lim

Hun S Oh

Jae Ho Cheong

Woong Cho

Jae S Rim

Chang U Hur

Seok Gu Kang

Jong Hee Chang

Woo B Choi

Soon Im Lee

Ho S Lee

Ji Hyun Lee

Seo-il Kim

Sang K Yoo

Yeong T Bae

Byoung B Lee

Mi Jeong Kim

Jun Jeong Choi

The present invention relates to a guanidine compound and a use thereof, and more specifically, to a guanidine derivative showing excellent effects of inhibiting cancer cell proliferation, cancer metastasis, and cancer recurrence; a preparation method thereof; and a pharmaceutical composition containing the same as an active ingredient. Compared to existing drugs, the guanidine derivative according to the present invention shows excellent effects of inhibiting cancer cell proliferation, cancer metastasis, and cancer recurrence even with small doses, and may thus be effectively used in preventing or treating various cancers such as uterine cancer, breast cancer, stomach cancer, brain cancer, rectal cancer, colorectal cancer, lung cancer, skin cancer, blood cancer, liver cancer, etc., inhibiting cancer cell proliferation and cancer metastasis.

Biguanide compound and use thereof

The present invention relates to guanidine compounds for inhibiting mitochondrial oxidative phosphorylation (OXPHOS) and use thereof. More specifically, the present invention relates to a pharmaceutical composition for preventing or treating a OXPHOS-related disease, particularly cancer, by inhibiting mitochondrial oxidative phosphorylation and reprogramming cellular metabolism.

Guanidine compounds and use thereof

The present invention relates to guanidine compounds for inhibiting mitochondrial oxidative phosphorylation (OXPHOS) and use thereof. More specifically, the present invention relates to a pharmaceutical composition for preventing or treating a OXPHOS-related disease, particularly cancer by inhibiting mitochondrial oxidative phosphorylation and reprogramming cellular metabolism.

The present invention relates to biguanide compounds and use thereof, more particularly, to biguanide derivatives exhibiting excellent effects for inhibition of cancer cell proliferation and inhibition of cancer metastasis and recurrence, a method for preparing the same, a pharmaceutical composition containing the same as an active ingredient, and a method of prevention or treatment of cancer comprising the step of administering an effective amount of the composition to a subject in need thereof.

Biguanide compounds and use thereof

The present invention provides novel uses of a biguanide derivative for preventing or treating glioblastoma. The compound of Formula 1 and its pharmaceutically acceptable salts can be used for preventing and treating glioblastoma. Further, the combined treatment of the compound of Formula 1 and temozolomide can provide superior effects compared to the administration of the compound of Formula 1 alone or temozolomide alone.

Pharmaceutical composition comprising a biguanide derivative as an active ingredient for preventing or treating glioblastoma

The invention relates to novel herbicidal compounds and compositions. The compounds of the invention are highly substituted derivatives of pyrimidine.

Herbicidal pyrimidine derivatives, process for preparation thereof and

The present invention relates to 6-chloro-2-(4,6-dimethoxypyrimidin-2-yl)oxybenzoic acid iminoester derivative of the general formula I; process of their preparation and a method for their application as herbicides: ##STR1## wherein R and Q are as defined in the specification.

6-chloro-2-(4,6-dimethoxypyrimidin-2-yl)oxybenzoic acid imino ester

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Daejeon, South Korea

Hong Woo Kim