Academia Sinica

Other

Elixiron Immunotherapeutics (hong Kong) Limited

Hong-Sen Chen

An-Suei Yang

Chung-Ming Yu

Yi-Kai Chiu

Chao-Ping Tung

Chi-Huey Wong

Chun-Hung Lin

Chun-Cheng Lin

Shui-Tein Chen

Hwei-Jiung Wang

Ing-Chien Chen

Hung-Ju Hsu

Shin-Chen Hou

Wei-Ying Kuo

Yuan-Yuan Wang

Kay-Hooi Khoo

Yueh-Liang Tsou

Yow-Fu Tsai

Hung-Pin Peng

Jhih-Wei Jian

Chi-Kai Yang

Cheng-Chung Lee

Shih-Hsien Chuang

Hung-Kai Chen

Michael Hsiao

Yu-Chi Chou

Yi-Jen Huang

Chao-Pin Lee

Huey-Wen Hsiao

Ing-Chein Chen

Chia-Lung Lin

The present disclosure provides antibodies, including antibody fusions, which specifically bind to human PD-L1 protein (huPD-L1) and are capable of decreasing, inhibiting, and/or fully-blocking immune regulatory effects mediated by PD-L1, such as binding to the immune checkpoint molecule PD-1 in the tumor microenvironment. Additionally, the antibodies include fusions with the cytokine inhibitory factor, IL10, which can replenish and/or activate CD8+ T-cell cytotoxicity in the tumor microenvironment. The present disclosure also provides methods of using the antibodies (and compositions thereof) to treat diseases and conditions responsive to decreasing, inhibiting and/or blocking immune regulatory function or activity mediated by PD1 binding to PD-L1.

Anti-PD-L1 antibodies and anti-PD-L1/IL10 fusion proteins

Disclosed herein are methods for high-throughput screening of a virus-specific neutralizing antibody. According to certain embodiments of the present disclosure, the virus is an influenza virus. Also disclosed herein are the antibodies selected by the high-throughput screening method, and the uses thereof in the prophylaxis and/or treatment of viral infection.

Method for high-throughput screening of neutralizing antibodies, neutralizing antibodies produced therefrom, and uses thereof

Disclosed herein are methods for high-throughput screening of a functional antibody fragment for an immunoconjugate that targets a protein antigen. The method combines a phage-displayed synthetic antibody library and high-throughput cytotoxicity screening of non-covalently assembled immunotoxins or cytotoxic drug to identify highly functional synthetic antibody fragments for delivering toxin payloads.

High-throughput screening of functional antibody fragments, immunoconjugate comprising the same, and adaptor-drug conjugate for screening

Disclosed herein is an immunoconjugate comprising an antibody, a functional motif, and a linker connecting the functional motif to the antibody. According to embodiments of the present disclosure, the antibody may recognize tumor-associated antigens (TAAs), and serves as a targeting module for delivering the functional motif connected therewith to the tumor cells thereby inhibiting tumor growth or detecting the distribution of tumor cells. Also disclosed herein are methods of treating cancers and methods of diagnosing cancers by use of the present immunoconjugate.

Immunoconjugate and uses thereof

Disclosed herein is a phage-displayed single-chain variable fragment (scFv) library, that comprised a plurality of phage-displayed scFvs characterized with (1) a specific CS combination; (2) a specific distribution of aromatic residues in each CDR; and (3) a specific sequence in each CDR. The present scFv library could be used to efficiently produce different antibodies with binding affinity to different antigens. Accordingly, the present disclosure provides a potential means to generate different antigen-specific antibodies promptly in accordance with the need in experimental researches and/or clinical applications.

Recombinant antibody and uses thereof

Disclosed herein is a phage-displayed single-chain variable fragment (scFv) library, which comprises a plurality of phage-displayed scFvs characterized in having a specific CS combination and a specific sequence in each CDR. The present scFv library is useful in efficiently producing different antibodies with binding affinity to different antigens. Accordingly, the present disclosure provides a potential means to generate different antigen-specific antibodies promptly in accordance with the need in experimental researches and/or clinical applications.

Phage-displayed single-chain variable fragment libraries and uses thereof

Phage-displayed single-chain variable fragment library

The present invention provides methods of modulating an immune response in an organism by administering medicinally active extracts and fractions, and a method for preparing the same by extracting and fractioning constituents from the tissue of components of

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The present invention provides medicinally active extracts and fractions, and a method for preparing the same by extracting and fractioning constituents from the tissue of components of. These active extracts and fractions are useful for inhibiting tumor growth, modulating immune response, and increasing hematopoietic activity.

Immuno-modulating antitumor activities of ganoderma lucidum (reishi) polysaccharides

The present invention provides medicinally active extracts and fractions, and a method for preparing the same by extracting and fractioning constituents from the tissue of plant components of. These active extracts and fractions are useful for inhibiting tumor growth, modulating immune response, and increasing hematopoietic activity.

Growing community of inventors

Taipei, Taiwan

Hong-Sen Chen