Everfront Biotech Inc.

National Chung Hsing University

National Dong Hwa University

Taiwan Mitochondrion Applied Technology Co., Ltd.

Ejia Biotechnology Co., Ltd.

Taiwan Mitochondrion Applied Technology

Hong-Lin Su

Shinn-Zong Lin

Horng-Jyh Harn

Tzyy-Wen Chiou

Shiaw-Min Hwang

Ping-Shan Lai

Chia-Yu Chang

Huai-En Lu

Sheng-Feng Tsai

Hsiu-Chin Lee

Shih-Ping Liu

Chun-Wei Chuang

Hung-Chuan Pan

Sheng-Mei Chen

Hong-Meng Chuang

Kang-Yun Lu

Jeanne Hsieh

Chia-yu Chang

Applications of butylidenephthalide (BP), comprising the use of BP in providing a kit for promoting differentiation of stem cells into brown adipose cells, and the use of BP in preparing a medicament, wherein the medicament is used for inhibiting the accumulation of white adipose cells, promoting the conversion of white adipose cells into brown adipose cells, inhibiting weight gain and/or reducing the content of triglycerides, glucose, and total cholesterol in blood.

Applications of butylidenephthalide

This present invention provides a method for continuously maintaining growth of a motor neuron progenitor cell and a pharmaceutical composition. Wherein, the method for continuously maintaining growth of a motor neuron progenitor cell is to culture the motor neuron progenitor cell in an environment which is constructed by the olfactory ensheathing cells to make the motor neuron progenitor cell sustain the ability to self-replicate and to be induced for differentiating into mature neuron, and therefore to elaborate the effect to protect the motor neuron. The motor neuron progenitor cell produced from the method disclosed in this present invention can be an effective ingredient of the pharmaceutical composition for treating related diseases of damaged motor neuron.

Method and pharmaceutical composition for continuously maintaining growth of a motor neuron progenitor cell

A method for at least one of activating autoimmune system and treating cancer is provided. The method comprises administering to a subject in need an effective amount of Z-butylidenephthalide and an effective amount of mononuclear cells.

Use of Z-butylidenephthalide in activating autoimmune system

The present invention discloses use of butylidenephthalide (Bdph), a method of using the same, and a method for preparing a pharmaceutical composition containing the same. Because Bdph has the capability of promoting the hair growth and reducing the &#x3b2;-amyloid protein (A&#x3b2;) level in nerve cells, the efficacy of improving the health and appearance of a subject can be achieved by administrating an effective amount of Bdph to the subject. Specifically, the Bdph has the efficacy of preventing or treating neurodegenerative diseases such as Alzheimer's disease caused by excessive build up of A&#x3b2; in the cells, and as an active ingredient in a topical composition, the Bdph is effective in promoting the hair growth at the site where the Bdph is administered. Furthermore, the method for preparing a pharmaceutical composition containing Bdph comprises preparing the pharmaceutical composition through an organic synthesis reaction, wherein the Bdph is coated with a polymeric material such as F127 by covalent bonding of the polymeric material with the Bdph, thereby achieving the effect of reducing the cytotoxicity of the pharmaceutical composition for an organism.

Use of butylidenephthalide (Bdph), method of using the same, and method for preparing pharmaceutical composition containing the same

The present invention discloses a culture medium and method for inducing differentiation of pluripotent stem cells into neuroepithelial cells. The culture medium comprises at least two agents for neural induction, wherein the agents includes a Wnt signal agonist and a Smad2/3 inhibitor and the culture medium is a feeder free culture. The method is to culture pluripotent stem cells in the culture medium to differentiate into neuroepithelial cells. The neuroepithelial cells can further differentiate into mature neurons for practical applications, including regeneration medicine and drug discovery for neural disorders.

Culture medium and method for inducing differentiation of pluripotent stem cells into neuroepithelial cells

The present invention relates to a method of delaying the onset of pulmonary fibrosis or treating pulmonary fibrosis, comprising administering to a subject in need an effective amount of an active ingredient selected from the group consisting of a compound of formula (I), a pharmaceutically acceptable salt of the compound of formula (I), and combinations thereof: wherein,

Method for delaying the onset of pulmonary fibrosis or treating pulmonary fibrosis

Disclosed are a novel pharmaceutical composition and use thereof, the novel pharmaceutical composition at least comprising an effective amount of mitochondria and at least one pharmaceutically acceptable carrier; the novel pharmaceutical composition is administered to an individual to send the mitochondria into injured or subject-to-oxidative-stress lung cells; thus treating or improving lung injury or related diseases thereof.

Method for treating lung injury and/or diseases related to lung injury

Growing community of inventors

Taichung, Taiwan

Hong-Lin Su