National Skin Centre (Singapore) Pte Ltd

Other

Agency for Science, Technology and Research

Hong Liang Tey

Jiang Liu

Wing Kee Damon Wong

Chee Yen Lim

Jun Cheng

Ai Ping Yow

Ruchir Srivastava

Annan Li

Carolin Wall

The present invention provides a new treatment for idiopathic hypohidrosis. In one embodiment, the said treatment comprises administering to a patient in need a pharmaceutically effective amount of a retinoid. Preferably, the retinoid is isotretinoin or acitretin.

Treatment of idiopathic hypohidrosis

In the preferred embodiment of the present invention, a patch of dissolving microneedles loaded with active ingredients to be applied to skin for treating skin conditions is provided. As seen in FIG.the dissolving microneedle patch () comprises a substrate () and a plurality of microneedles () which extends from the substrate. The dissolving microneedle patch () is made of a matrix material and at least one active ingredient such as a corticosteroid, namely triamcinolone (TAC). The matrix material is made of bio-compatible materials such as hyaluronic acid (HA), polyvinylpyrrolidone (PVP), or mixture of them, which dissolve rapidly when they are in contact with the inner skin. The active ingredient is loaded onto individual patches with the desirable dosage ranging from 0.01 mg-1.0 mg.

Dissolving microneedle patches comprising corticosteroid

The present disclosure generally relates to an automated method and system for generating a three-dimensional (3D) representation of a skin structure of a subject. The method comprises: acquiring a plurality of two-dimensional (2D) cross-sectional images of the skin structure, specifically, using optical coherence tomography (OCT) technique; computing a cost for each 2D cross-sectional image based on a cost function, the cost function comprising an edge-based parameter and a non-edge-based parameter; constructing a 3D graph from the 2D cross-sectional images; and determining a minimum-cost closed set from the 3D graph based on the computed costs for the 2D cross-sectional images, wherein the 3D representation of the skin structure is generated from the minimum-cost closed set.

Three-dimensional representation of skin structure

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Singapore, Singapore

Hong Liang Tey