Ludwig Institute for Cancer Research Limited

Paracrine Therapeutics Ab

Hong Li

Ulf Eriksson

Andrew Ewart Scott

Xuri Li

Karin Aase

Annica Ponten

Laura Allan

The present invention relates, in part, to isolated antibodies that specifically interact with and show measurable binding affinity to an epitope of platelet derived growth factor C (PDGF-C). Such antibodies may be used for the modulation of PDGF-C activity in or secreted from a cell to study its effects on cell function and, in certain embodiments, for the treatment and/or prevention of a disease or condition associated with PDGF-C signing pathway.

Methods and compositions for PDGF-CC inhibition

Non-human transgenic animals overexpressing PDGF-C and cells thereof have been created. The transgenic animals contain a nucleotide sequence that encodes for platelet derived growth factor C (PDGF-C) or an analog thereof, or a functional fragment of PDGF-C or analog thereof. These animals are useful for studying disease states characterized by overexpression of PDGF-C, as well as useful for evaluating therapies intended to treat such diseases.

Non-human transgenic animals expressing platelet-derived growth factor C (PDGF-C) and uses thereof

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Sollentuna, Sweden

Hong Li