Amorepacific Corporation

Hong-Ju Shin

Yung Hyup Joo

Heung Soo Baek

Jeong Hwan Kim

Song Seok Shin

Jon Hwan Lee

Chang-Geun Yi

Do-Hoon Kim

Jeong-Hwan Kim

Won Seok Park

Hyun Ju Koh

Yongjin Kim

Jong Hee Park

Chang Seok Lee

Yong Jin Kim

Mi Jin Park

Kyung Ho Choi

Hyoung Jun Kim

Ho Sik Rho

Yong Deog Hong

Sung Il Park

Byoung Young Woo

Hyung Jun Lim

John Hwan Lee

Yeon Su Jeong

Hae Kwang Lee

Chang Geun Yi

Jung A Seo

Shin Young Park

Soo Jeong Choi

Suil Kim

Jeong Ah Hwang

Doo Hyun Baek

Shinbeom Kang

The present specification relates to a composition for external application to skin with improved solubility and feeling during use, comprising a benzoic acid amide compound, an isomer thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof or a solute that is a solvate thereof, and a first cyclodextrin solubilizing agent.

Composition comprising benzoic acid amide compound and cyclodextrin solubilizing agent

In one aspect of the present specification, provided is a method for predicting a side effect of a whitening ingredient, the method comprising measuring at least one of i) the increase in toxicity according to long-term use of a whitening ingredient, ii) the difference between a concentration having whitening effect and a concentration having cell toxicity, and iii) the increase in sensitivity to the whitening ingredient according to ultraviolet pretreatment. In addition, the method has an effect of effectively predicting whether a side effect will occur if the whitening ingredient is used for a long time.

Method for predicting side effect of whitening ingredient

The present invention relates to a method for preparing a benzoic acid amide compound in a high yield by presenting a novel method for preparing a benzyl amine compound to be used as a reactant and delimiting the reaction condition of each step by using the same, and the method is economically advantageous since mass production is possible.

Method for preparing benzoic acid amide compound

Disclosed is a novel adamantine derivative compound, an isomer thereof, pharmaceutically acceptable salt thereof, prodrug thereof, hydrate thereof or a solvate thereof. Also disclosed is a method for preparing a novel adamantine derivative compound, an isomer thereof, pharmaceutically acceptable salt thereof, prodrug thereof, hydrate thereof or a solvate thereof. The novel adamantane derivative compound or the like has an excellent anti-androgenic effect.

Adamantane derivative compound

Disclosed are a novel benzoic acid amide derivative compound, an isomer thereof, a pharmaceutically acceptable salt thereof, a prodrug thereof, a hydrate thereof, or a solvate thereof. The novel compound and the like inhibit melanin production, prevent tyrosinase activity, and have an excellent skin whitening effect.

Benzoic acid amide compound

Disclosed is a composition containing an active ingredient or ingredients comprising an extract or extracts of one or more constituents selected from the group consisting of, rose, rhubarb,and cortex. The composition is efficacious in suppressing acneiform pigment deposition and/or pitted scars, and can be used to advantage in various ways in the fields of cosmetics, foods and drugs.

Composition containing a natural extract

Disclosed is herein a composition comprising hexamidines, derivatives thereof, or pharmaceutically acceptable salts thereof; and retinoids, derivatives thereof, or pharmaceutically acceptable salts thereof, as an active ingredient. The composition of the present invention has effects for preventing, improving or treating acne; controlling sebum; pore-controlling; and preventing, improving or treating skin pigmentation. Also, the composition of the present invention could alleviate skin-irritations caused with retinoids by including ceramides.

Composition for skin improvement comprising hexamidines and retinoids

5-Adamantan-1-yl-N-(2,4-dihydroxybenzyl)-2,4-dimethoxybenzamide disclosed in the present disclosure lacks toxicity and can exhibit superior anti-inflammatory effect. It exhibits superior anti-inflammatory effect, for example, by inhibiting the production of one or more of NO and PGE2, by inhibiting the activity of one or more of the transcription factors NF-&#x3ba;B and AP-1 or by inhibiting proinflammatory cytokines such as IL-1&#x3b2;.

Composition for anti-inflammation containing 5-adamantan-1-yl-N-(2,4-dihydroxy-benzyl)-2,4-dimethoxy-benzamide

Growing community of inventors

Yongin-si, South Korea

Hong-Ju Shin