Washington University

Hong Jiang

David Michael Holtzman

Mark S Dennis

Yin Sheng Zhang

Ryan Jefferson Watts

Adam P Silverman

Jing Guo

Thu Nga Bien-Ly

Marc Diamond

Brandon B Holmes

Najla Kfoury

Fan Liao

Jason Ulrich

The present disclosure encompasses anti-TREM-2 antibodies that promote TREM-2 activation and methods of using the anti-TREM-2 agonist antibodies therapeutically.

Anti-TREM-2 agonist antibodies

The present disclosure encompasses compositions and methods for effectively treating at least one symptom or sign of Aß plaque or cerebral amyloid angiopathy (CAA) associated symptoms, or for decreasing amyloid plaque load or CAA load. The method comprises administering an effective amount of an anti-ApoE antibody to a mammalian subject, such as to a human.

Anti-ApoE antibodies

The present disclosure encompasses compositions and methods for effectively treating at least one symptom or sign of A plaque or cerebral amyloid angiopathy (CAA) associated symptoms, or for decreasing amyloid plaque load or CAA load. The method comprises administering an effective amount of an anti-ApoE antibody to a mammalian subject, such as to a human.

This invention relates to antibodies to tau and methods of use thereof.

Antibodies to tau

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St. Louis, MO, United States of America

Hong Jiang