Hutchison Medipharma Limited

Hutchison Medipharma Enterprises Limited

Hutchinson Medipharma Limited

Hong Jia

Wei-Guo Su

Weihan Zhang

Guangxiu Dai

Yang Sai

Xiaoqiang Yan

Jifeng Duan

Yumin Cui

Yongxin Ren

Yu Cai

Wenji Li

Zhenping Wu

Zhenping Tian

Jiangyong Shao

Tao Wang

Weiguo Su

Rick B Ye

Provided are certain triazolopyridines and triazolopyrazines of Formula 1, wherein X, Y, R, R, R, Rand Rhave any of the meanings described herein; processes for their preparation, pharmaceutical compositions containing them, and their use in the treatment of cell proliferative disorders.

Certain triazolopyridines and triazolopyrazines, compositions thereof and methods of use therefor

Provided are certain triazolopyridines and triazolopyrazines, compositions thereof and methods of use therefor.

Compound of Formula A and pharmaceutically acceptable salts thereof and crystalline Forms I and II of Compound of Formula A! Also, methods for the preparation of such compounds, pharmaceutical compositions comprising such compounds, and methods for their uses.

Compound, certain novel forms thereof, pharmaceutical compositions thereof and methods for preparation and use

A compound of the following formula: wherein R, R, R, R4, R5, T, U, V, X, Y, Z, G, and Z are defined herein. It also discloses a method of treating an angiogenesis-related disorder, e.g., cancer or age-related macular degeneration, with such a compound.

Pyrimidine derivatives

Provided are certain triazolopyridines and triazolopyrazines of Formula 1. wherein X, Y, R, R, R, Rand Rhave any of the meanings described herein; processes for their preparation, pharmaceutical compositions containing them, and their use in the treatment of cell proliferative disorders.

Pyrimidine compounds of the following formula: wherein R, R, R, R, R, X, Q, Q, and Qare defined herein. Also disclosed is a method of treating cancer with one of these compounds.

Pyrimidine compounds

Disclosed are methods for inhibiting TNF&#x3b1; expression, IL-1&#x3b2; expression, iNOS expression, and NF-&#x3ba;B activity and methods for treating autoimmune disease, cancer, or atherosclerosis with a compound of the following formula: 

Costunolide derivatives

A compound of the following formula: wherein X, Y, and Z are as defined herein. Also disclosed are methods for inhibiting TNF&#x3b1; expression, IL-1&#x3b2; expression, iNOS expression, and NF-&#x3ba;B activity and methods for treating autoimmune disease, cancer, or atherosclerosis with such a compound.

Growing community of inventors

Shanghai, China

Hong Jia