Leland Stanford Junior University

Other

The John Innes Institute

Kosan Biosciences Incorporated

Pfizer Corporation

Kla-tenor Corp.

The John Innes Centre

The Johns Innes Institute

Hong Fu

Chaitan Khosla

Robert G McDaniel

David A Hopwood

Camilla M Kao

Suzanne Ebert-Khosla

David C Myles

Yaoquan Liu

Yue Chen

Susanne Ebert-Khosla

Daniel V Santi

Gary W Ashley

Yandong Li

Christopher Carreras

Leonard Katz

Steven R Lange

Yu Guan

Mark A Burlingame

Simon James Shaw

Yong Li

Hao Zheng

Carbamate compounds having a structure represented by formula I (where R, R, R, R, Rand Rare as defined herein) are useful as anti-tumor agents. 

Carbamate compounds

A compound having a structure according to formula I wherein R, R, R, R, and Rare as defined herein, are useful as kinase inhibitors.

Macrocyclic kinase inhibitors

Compounds having a structure according to formula (I) where R, R, R, R, R, and Rare as defined herein, are useful as prokinetic agents.

Motilide compounds

Novel polyketides and novel methods of efficiently producing both new and known polyketides, using recombinant technology, are disclosed. In particular, a novel host-vector system is described which is used to produce polyketide synthases which in turn catalyze the production of a variety of polyketides.

Recombinant production of novel polyketides

Sixteen membered macrolide anti-infective agents having a structure according to formula I where R, R, R, R, R, and Rare as defined herein, and related compounds are disclosed.

Sixteen-member macrolide antiinfective agents

Methods to prepare cells comprising heterologous polyketide synthase expression systems

Disclosed are methods and apparatus for designing an optical spectrum of an illumination light beam within an optical inspection system. A set of conditions for inspecting a film on a sample by directing an illumination light beam at the sample is determined. At least a portion of the illumination light beam is reflected off the sample and used to generate an image of at least a portion of the film on the sample. A plurality of peak wavelength values are determined for the optical spectrum of the illumination light beam so as to control color variation in the image of the film portion. The determination of the peak wavelengths is based on the determined set of conditions and a selected thickness range of the film. In one specific embodiment, the color variation is reduced, while in another embodiment the color variation is increased to enhance pattern contrast. An apparatus which implements the designed optical spectrum is also disclosed.

Apparatus and methods for reducing thin film color variation in optical inspection of semiconductor devices and other surfaces

Combinatorial libraries of polyketides can be obtained by suitable manipulation of a host modular polyketide synthase gene cluster such as that which encodes the PKS for erythromycin. The combinatorial library is useful as a source of pharmaceutically active compounds.

Modified modular PKS with retained scaffold

Recombinant combinatorial genetic library for the production of novel

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Union City, CA, United States of America

Hong Fu