Merck Sharp + Dohme Corp.

Hong-Dong Li

Yong Zhang

Guoqing Li

Subharekha Raghavan

Jianmin Fu

Cameron James Smith

Shouwu Miao

Yi-Heng Chen

John E Stelmach

Alan Whitehead

Joie Garfunkle

Rui Zhang

Gang Ji

Raphaelle Berger

Falong Jiang

The invention provides compounds of the Formula (I) or a pharmaceutically acceptable salts thereof, wherein X, Y, Z, R, R, R, R, and the subscripts m, p, and q are as described herein. The compounds or their pharmaceutically acceptable salts can modulate the body's production of cyclic guanosine monophosphate ('cGMP'), and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The invention also provides pharmaceutical compositions which comprise compounds of Formula (I) or pharmaceutically acceptable salts thereof. The invention also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose.

Soluble guanylate cyclase stimulators

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Edison, NJ, United States of America

Hong-Dong Li