Il Dong Pharmaceutical Co., Ltd.

Daewoong Pharmaceutical Co., Ltd.

Daewoong Co., Ltd.

Hong Chul Yoon

Jung Ho Kim

Kyung Mi An

Jung Woo Lee

Sang Ho Lee

Jae Eui Shin

Da Hae Hong

Woo Jin Jeon

Min Whan Chang

Gunhee Kim

Jin Hee Lee

In Woo Kim

Ji Duck Kim

Jeong-Geun Kim

Jung-eun Park

Yearin Jun

Changhee Hong

Changmok Oh

Te-ik Sohn

Jin Ah Jeong

Eun Hye Jang

In-Gyu Je

Myong Jae Lee

Ji Hye Choi

Yeongran Yoo

Sung Wook Kwon

Kyeojin Kim

Jaeho Heo

A-rang Im

In Young Lee

Soo Jin Choi

Joon Hwan Lee

Hyae Jung Hyun

Byung Goo Lee

Hee Kyoon Yoon

Sang Hyun Nam

Min Jae Cho

Jung Eun Park

Joon Tae Park

Yeong Ran Yoo

In Gyu Je

Su Yeon Kang

Chang Hee Hong

Young Mook Lim

Joo Yun Lee

Kwon Jo Lim

Rang A Im

Yoon Sung Song

Jae Ho Heo

Te Ik Sohn

Ji Duck 401-1701 Seohong Maeul Hyosung Apt Kim

Jung-Eun Park

Te-Ik Sohn

A Rang Im

Eun Kyung Park

A-Rang Im

Disclosed are novel compounds of Chemical Formula 1, optical isomers of the compounds, and pharmaceutically acceptable salts of the compounds or the optical isomers. The compounds, isomers, and salts exhibit excellent activity as GLP-1 receptor agonists. In particular, they, as GLP-1 receptor agonists, exhibit excellent glucose tolerance, thus having a great potential to be used as therapeutic agents for metabolic diseases. Moreover, they exhibit excellent pharmacological safety for cardiovascular systems.

GLP-1 receptor agonist and use thereof

The present invention provides a novel compound represented by Chemical Formula 2, or a pharmaceutically acceptable salt thereof. The novel compound according to the present invention exhibits an excellent acid secretion inhibitory effect.

Acid secretion inhibitor and use thereof

Disclosed herein are novel benzoimidazole derivatives functioning as antagonists to vanilloid receptor-1, and a pharmaceutical composition comprising the same. They are useful in preventing or treating pain, acute pain, chronic pain, neuropathic pain, postoperative pain, migraines, arthralgia, neuropathy, nerve injury, diabetic neuropathy, neurological illness, neurodermatitis, strokes, bladder hypersensitivity, irritable bowel syndrome, respiratory disorders such as asthma, chronic obstructive pulmonary disease, etc., burns, psoriasis, itching, vomiting, irritation of the skin, eyes, and mucous membranes, gastric-duodenal ulcers, inflammatory intestinal diseases, and inflammatory diseases.

Benzoimidazole derivatives and pharmaceutical composition comprising the same

This invention relates to a method of preparing a benzoimidazole derivative at high purity and high yield so as to enable the production of the benzoimidazole derivative compound as an antagonist against a vanilloid reactor-1, and particularly to a method of preparing a benzoimidazole derivative at high purity and high yield, wherein the benzoimidazole derivative is synthesized using a novel intermediate, namely, benzaldehyde, and thereby the preparation process is simple so that it can be applied to production.

Method of preparing benzoimidazole derivatives

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Gyeonggi-do, South Korea

Hong Chul Yoon