Third Wave Technologies, Inc.

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Marilyn C Olson-Munoz

Sarah Olson

Michelle Curtis

Christian Tor Bartholomay

Hatim T Allawi

Victor I Lyamichev

Bruce P Neri

Jeff G Hall

Peggy S Eis

Michael W Kaiser

Robert W Kwiatkowski, Jr

Andrew A Lukowiak

LuAnne Chehak

Tsetska Y Takova

James J Schaefer

Kevin L Vedvik

WuPo Ma

Lin Ji

Zbigniev Skrzypczynski

Robert W Kwiatkowski

Natalie E Lyamicheva

Lisa C Thompson

Brad T Argue

Tamara J Sander

Vecheslav A Elagin

Poonam Agarwal

Angela Hudson

Ilse Tyler

Michelle Garsha

Andrea L Mast

Zbigniew Skrzypczynski

Molly Accola

Susan S Wigdal

Vincent Tevere

Natalie Lyamichev

Slava Elagin

The present invention provides compositions and methods for the detection and characterization of HPV sequences. More particularly, the present invention provides compositions, methods and kits for using invasive cleavage structure assays (e.g. the INVADER assay) to screen nucleic acid samples, e.g., from patients, for the presence of any one of a collection of HPV sequences. The present invention also provides compositions, methods and kits for screening sets of HPV sequences in a single reaction container.

Detection of HPV

The present invention provides novel cleavage agents and polymerases for the cleavage and modification of nucleic acid. The cleavage agents and polymerases find use, for example, for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. In some embodiments, the 5' nuclease activity of a variety of enzymes is used to cleave a target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.

RNA detection assays

The present invention provides compositions and methods for the detection and characterization of mutations associated with cystic fibrosis. More particularly, the present invention provides compositions, methods and kits for using invasive cleavage structure assays (e.g. the INVADER assay) to screen nucleic acid samples, e.g., from patients, for the presence of any one of a collection of mutations in the CFTR gene associated with cystic fibrosis. The present invention also provides compositions, methods and kits for screening sets of CFTR alleles in a single reaction container.

CFTR allele detection assays

Detection of RNA Sequences

Growing community of inventors

Madison, WI, United States of America

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