Hoffmann-la Roche Inc.

American Cyanamid Company

Homer D Tresner

John Westley

Chao-Min Liu

Donald B Borders

Amedeo A Fantini

William J McGahren

John H Martin

John Norman Porter

There are provided antibiotics X-14873 A, G and H of the formulas ##STR1## wherein for X-14873A, R.sub.1 is CO.sub.2 H and R.sub.2 is ##STR2## for X-14873G, R.sub.1 is hydrogen and R.sub.2 is ##STR3## and for X-14873H, R.sub.1 is hydrogen and R.sub.2 is ##STR4## The compounds exhibit antibiotic activity. Also disclosed is a process to produce the above compounds.

Process to produce antibiotics X-14873 A, G and H

There is presented an antibiotic compound of the formula ##STR1## and the pharmaceutically acceptable salts and esters thereof. The compound exhibits activity as an anti-swine dysentery agent and an antimicrobial agent. Also presented is a fermentation process to produce the compound of formula I.

Process to produce antibiotic X-14885A

Antibiotics X-14873 A, G and H

Antibiotic X-14885A

This disclosure describes three new antibiotics designated BM782.alpha.1, BM782.alpha.2, and BM782.alpha.1a which are produced in a microbiological fermentation under controlled conditions using a new strain of an undetermined species of the genus Nocardia or mutants thereof. These new antibacterial agents are active against Mycobacterium tuberculosis as well as both gram-positive and gram-negative microorganisms and thus are useful for inhibiting the growth of such bacteria and bacilli wherever they may be found.

Antibacterial antibiotic BM782

This disclosure describes 5 new antibacterial agents designated BM123.alpha., BM123.beta. .sub.1, BM123.beta..sub.2, BM123.gamma..sub.1, and BM123.gamma..sub.2 produced in a microbiological fermentation under controlled conditions using a new strain of an undetermined species of Nocardia and mutants thereof. The new antibacterial agents are active against a variety of microorganisms and thus are useful in inhibiting the growth of such bacteria wherever they may be found.

Antibiotic BM123 and production thereof

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LaFarge, WI, United States of America

Homer D Tresner