Evotec International Gmbh

Padlock Therapeutics, Inc.

Max-Planck-Gesellschaft Zur F&#xf6;rderung Der Wissenschaften E. V.

Forge Therapeutics, Inc.

Blacksmith Medicines, Inc.

Holly Atton

Heather Tye

Mirco Meniconi

Serge Convers-Reignier

Min Teng

Gnanasambandam Kumaravel

David Thomas Puerta

Rajesh Devraj

Christopher John Brown

Xiaoming Li

Cristina Lecci

Baskar Nammalwar

Laura Gleave

Ian Yule

Elise Gadouleau

Jordan Palfrey

Philip Stephen Kerry

Edward Beaumont

Nat Monck

James Lindsay Carr

Daryl Simon Walter

Michelle Southey

Jonathan Paul Shine

Scott Alexander Sadler

Kostas Papadopoulos

Adele Faulkner

Christian Perez

Alastair Parkes

Philip A Woods

John Michael McCall

Eddine Saiah

Hairuo Peng

Kai Peter Johnsson

Mark Joseph Tebbe

Mark Peter Ridgill

Christopher Francis Palmer

Mark Anthony Kerry

Adrian Kotey

Steven Mark Bromidge

Nathaniel J Monck

Katarzyna Irena Gorska

Adrian Kotei Kotey

Mohamad Sabbah

Michael Corr

Marissa Flower

Irena Reboule

Craig Avery

Mark Kerry

Phillip Stephen Kerry

The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts, solvates, hydrates, tautomers or stereoisomers thereof, wherein R, R, R, R, R, R, R, R, R, R, Aand Ahave the meaning as indicated in the description and claims. The invention further relates to pharmaceutical compositions comprising said compounds, their use as medicament and in a method for treating and preventing of one or more diseases or disorders associated with integrated stress response.

Modulators of the integrated stress response pathway

Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting the growth of gram-negative bacteria. Furthermore, the subject compounds and compositions are useful for the treatment of bacterial infection, such as urinary tract infection and the like.

Antibacterial compounds

The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts, solvates, hydrates, tautomers or stereoisomers thereof, wherein R, R, R, R, R, R, R, R, R, X, X, Aand Ahave the meaning as indicated in the description and claims. The invention further relates to pharmaceutical compositions comprising said compounds, their use as medicament and in a method for treating and preventing of one or more diseases or disorders associated with integrated stress response.

The present invention provides compounds useful as inhibitors of PAD4, compositions thereof, and methods of treating PAD4-related disorders.

Heteroaryl inhibitors of PAD4

Provided herein are heterocyclic derivative compounds of Formula (II), and pharmaceutical compositions comprising said compounds that are useful for inhibiting the growth of gram-negative bacteria. Furthermore, the subject compounds and compositions are useful for the treatment of bacterial infection, such as urinary tract infection and the like. 

Inhibitors of sepiapterin reductase and uses of sepiapterin reductase inhibitors in analgesia, treatment of acute and chronic pain, anti-inflammation, and immune cell regulation are disclosed.

Sepiapterin reductase inhibitors

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Abingdon, United Kingdom

Holly Atton