University of Michigan

Wayne State University

Hollis Showalter

Scott D Larsen

Alan Robert Saltiel

Zaneta Nikolovska-Coleska

Christiane Wobus

Fardokht Abulwerdi

Nicholas J Donato

Moshe Talpaz

Roderick J Sorenson

Monika Ermann

Jeanne Stuckey

Yafei Jin

Daniel H Teitelbaum

James Varani

John J Tesmer

Lei Miao

Ahmed Mady

Chenzhong Liao

Hiroyuki Koga

Andy D White

Xinmin Gan

Matthew Young

Mary Xuan Dziem O'Riordan

Ramzi Mohammad

Jeffrey W Perry

Mary X O'Riordan

Peter Lucas

Kent J Johnson

Luke Peterson

This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a dimethyl-nonatetraenyl-trimethyl-cyclohexyl structure useful as therapeutics for the treatment of subjects suffering from disorders characterized by abnormal proliferation and/or abnormal differentiation of cells, in particular of cells of which the growth and differentiation is sensitive to the actions of retinoids.

Dimethyl-nonatetraenyl-trimethyl-cyclohexyl compounds and uses thereof

Provided herein is technology relating to deuterated amlexanox and particularly, but not exclusively, to compositions comprising deuterated amlexanox, methods of producing deuterated amlexanox, and uses of deuterated amlexanox.

Deuterated amlexanox

Provided herein are amlexanox analogs and methods for the treatment and/or prevention of diabetes, impaired insulin signaling, obesity, or other related diseases and conditions therewith.

Amlexanox analogs

Disclosed herein are methods of inhibiting a deubiquitinase (DUB) by contact with a compound of formula (I). 

Deubiquitinase inhibitors and methods for use of the same

This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having sulfonamido-1-hydroxynaphthalene structure which function as inhibitors of Mcl-1 protein, and their use as therapeutics for the treatment of cancer and other diseases.

Small molecule inhibitors of Mcl-1 and the uses of thereof

This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having pyrazolopyridine structure which function as inhibitors of Mcl-1 protein, and their use as therapeutics for the treatment of cancer and other diseases.

Small molecule inhibitors of MCL-1 and uses thereof

Provided herein is technology relating to deuterated amiexanox and particularly, but not exclusively, to compositions comprising deuterated amiexanox, methods of producing deuterated amiexanox, and uses of deuterated amiexanox. Provided herein are deuteratecl amiexanox compounds for the treatment of obesity, insulin resistance, diabetes, and steatosis. In addition, the deuterated compounds are anti-inflammatory antiallergic immunomodulators. e.g., for the treatment of diseases associated with inflammation. The deuterium kinetic isotope effect associated with placing deuterium at the site of metabolic derivatization slows metabolic derivatization and thus increases the lifetime of the active drug in vivo.

Disclosed herein are methods of inhibiting a deubiquitinase (DUB), methods of treating pathogenic infections (e.g., viral, bacterial, and/or parasitic), methods of inhibiting cell proliferation, methods of treating a neurodegenerative disease, methods of treating one or more symptoms of a neurodegenerative disease or a genetic disorder, and compounds, wherein the compound can have a structure of formula (III): 

The present invention provides compositions and methods for treating inflammatory conditions (e.g., of the bowel). In particular, the present invention provides methods of treating (e.g., therapeutically and/or prophylactically treating) inflammatory conditions (e.g., of the bowel), compositions useful for such methods (e.g., antagonists and/or inhibitors of angiotensin II (AngII) receptor Type 1a (AT1a)), and methods of identifying, characterizing and/or optimizing such compositions. Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine) and research applications.

Compositions and methods for treating inflammatory conditions of the bowel

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Ann Arbor, MI, United States of America

Hollis Showalter