Heraeus Deutschland Gmbh & Co Kg

W.c. Heraeus Gmbh

Soligenix, Inc.

Heraeus Precious Metals Gmbh & Co. Kg

Context Biopharma Inc.

Arumugham, Rasappa

Schaber, Christopher

Werner, Silvia

Rauter, Holger

Holger Rauter

Silvia Werner

Rasappa Gounder Arumugham

Christopher Schaber

Friedrich Wissmann

Richard Walter

Stefan Proniuk

Robert Sievi

Holger Bindernagel

Holger Albert Ulland

Dirk Born

Ulf Tilstam

Michael Gock

Kai Groh

Stefanie Schmengler

Andreas Pepels

Ralf-Dieter Schnebeck

Christian Brandes

Steffen Jost

Rasappa Arumugham

Brandes Christian

Werner Silvia

Schmengler Stefanie

Raimund Seliger

Platinum complex of the type [L1L2Pt[O(CO)R1]X], wherein L1 and L2 are the same or different monoolefin ligands or together represent a compound L1L2 acting as a diolefin ligand, wherein X is selected from bromide, chloride, iodide, and —O(CO)R2, wherein —O(CO)R1 and —O(CO)R2 are the same or different C6-C18 or C8-C18 non-aromatic monocarboxylic acid groups with the exception of a phenylacetic acid group, or together represent a C8-C18 non-aromatic dicarboxylic acid group —O(CO)R1R2(CO)O—, wherein it is a mononuclear platinum complex where n=1, or wherein, in the event of the presence of L1L2 and/or of —O(CO)R1R2(CO)O—, it may be a polynuclear platinum complex with a whole number n>1.

Platinum complexes

Improved systems and methods for producing synthetic hypericin at high volume and high purity. In particular, systems and methods of preparing a purified synthetic hypericin resulting from irradiation, wherein the irradiation step is performed in a continuous flow micro-reactor. The process of manufacturing purified synthetic hypericin results in the synthetic yield of 30-100% of the dry product.

Systems and methods for producing synthetic hypericin

Methods and systems for making intermediates in the synthesis of onapristone are provided. Aspects include the photoconversion of onapristone synthesis intermediates using a narrow band frequency light source.

Methods of making onapristone intermediates

Improved systems and methods for producing synthetic hypericin at high volume and high purity.

The present invention describes the dihydrate of 1,2-cyclohexanediaminplatinum(II)-bis-(4-methylbenzenesulfonate), a method for producing 1,2-cyclohexanediaminplatinum(II)-bis-(4-methylbenzenesulfonate) and the hydrates thereof, and the use of 1,2-cyclohexanediaminplatinum(II)-bis-(4-methylbenzenesulfonate) and of the hydrates thereof.

1,2-cyclohexanediaminplatinum(II)-bis-(4-methylbenzenesulfonate) and the hydrates thereof

Methods are provided for the production of bendamustine alkyl ester, bendamustine, as well as derivatives thereof. With the methods the production of these compounds is possible in reproducibly high yields. To this end, hydroxyl-group-containing esters are used as the starting material, whose hydroxyl groups are substituted in a simple way by halogen groups. This substitution is possible in the presence of (i) oxalyl chloride and (ii) dialkylformamide, dialkyl acetamide or dimethyl sulfoxide. In a subsequent reaction, the resulting esters can be hydrolyzed to form the acid.

Process for the production of bendamustine alkyl ester, bendamustine, and derivatives thereof

Methods for manufacturing 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxy-camptothecin are described comprising

Methods for preparing Irinotecan

A process for the preparation of diaminocyclohexane-platinum(II)-dicarboxylates has the following steps:  and removal of the resulting AgX precipitate. 

Process for the preparation of 1,2-diaminocyclohexane-platinum(II) complexes

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Flieden, Germany

Holger Rauter