The Scripps Research Institute

Emd Lexigen Research Center Corp.

Universitatsklinikum Charite Der Humboldt-universitat Zu

Universitätsklinikum Charité Der Humboldt- Universität Zu Berlin

Holger N Lode

Stephen D Gillies

David A Cheresh

Ralph A Reisfeld

Gerhard Gaedicke

Wolfgang Wrasidlo

The invention provides methods for treating tumors and tumor metastases in a mammal comprising administering, to a mammal in need of treatment, a therapeutic amount of an antagonist sufficient to inhibit angiogenesis in combination with a therapeutic amount of anti-tumor immunotherapeutic agent, such as a anti-tumor antigen antibody/cytokine fusion protein having a cytokine and a recombinant immunoglobulin polypeptide chain sufficient to elicit a cytokine-specific biological response.

Methods for treatment of tumors and metastases using a combination of anti-angiogenic and immuno therapies

The invention relates to podophyllotoxins, uses thereof and methods of their production.

Podophyllotoxin

The invention teaches methods for treating tumors and tumor metastases in a mammal comprising administering, to a mammal in need of treatment, a therapeutic amount of an antagonist sufficient to inhibit angiogenesis in combination with a therapeutic amount of anti-tumor immunotherapeutic agent, such as a anti-tumor antigen antibody/cytokine fusion protein having a cytokine and a recombinant immunoglobulin polypeptide chain sufficient to elicit a cytokine-specific biological response.

Growing community of inventors

Berlin, Germany

Holger N Lode