Miltenyi Biotec, Gmbh

Miltenyi Biotec B.v. Co., Kg

Plasmaselect Aktiengesellschaft

Miltenyi Biotec B.v. & Co. Kg

Holger Lantow

Winfried Schimmelpfennig

Stefan Miltenyi

Martin Biehl

Eiad Kabaha

Juergen Schulz

Niklas Elmar Neuschaefer

Jürgen Schulz

Elmar Niklas Neuschäfer

Niklas Elmar Neuschäfer

Elmar Niklas Neuschaefer

Wilfried Riggers

Uwe Muller

The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder, a pump and a plurality of valves configured to at least partially control fluid flow through a fluid circuitry and a separation column positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

Method for manufacturing a patient specific cell population using a multifunctional self-contained apparatus and tubing set

The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (), a pump () and a plurality of valves (-) configured to at least partially control fluid flow through a fluid circuitry and a separation column () positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

Devices and disposables for patient-specific cell therapy manufacturing

Single use tubing set for making genetically modified donor cells for reinfusion into a patient

Device and procedure for producing a cellular pharmaceutical product enriched in genetically modified target cells at the bedside or in a surgical room

Equipment and procedure for culturing, separating, and genetically modifying donor cells for reinfusion into a patient

Automated method for sterile processing of cells by centrifugation and column chromatography

Preparing genetically modified cells using a device that is configured for sterile processing of cells at the bedside or in a surgical room

Preparing antigen-specific T cells using a self-enclosed processing system that contains both a centrifuge and a magnetic separation column

Self-contained disposable tubing set for sterile preparation of cells by culturing, centrifugation, and column chromatography

The invention relates to a centrifuge for separating a sample into at least two components, comprising a chamber for receiving a sample to be centrifuged. According to the invention, the centrifuge further comprises a means for controlling the progress of the sample separation is located at the chamber.

Centrifuge for separating a sample into at least two components

System for separating a cell sample by centrifugation and column chromatography while maintaining sterility

The presently disclosed subject matter proposes an apparatus () and a method for transferring energy and/or a substance from a non-rotating component of an apparatus to a rotating device ()&#x2014;or vice versa&#x2014;through an intermediary component ('). In one configuration, the intermediary component (&#x2032;) is a symmetrically arranged pair of tubes, useful in centrifugal separation, and which is subject to continuous rotation while tube ends are fixed in a lower, stationary range or stand still.

Apparatus and method for transferring energy and/or a substance to rotating means

Sample processing system and methods

The present invention refers to a filtering device comprising at least one filtering membrane, at least one counter surface opposite to the filtering membrane, and at least one gap-shaped liquid space formed between the filtering membrane and the counter surface. The present invention further refers to a filtering method, in which a liquid is introduced into a gap-shaped liquid space formed between a filtering membrane and a counter surface and is moved relative to the filtering membrane and/or the counter surface. To obtain an improved filtering method and an improved filtering device, it is suggested by the present invention that the filtering device comprises a disk at whose circular surface at least the filtering membrane or the counter surface is formed. In the method according to the invention, two helical liquid whirls are generated in the gap-shaped liquid space, said whirls extending in parallel to the filtering membrane and the counter surface and having the same sense of rotation but opposite radial directions of movement.

Filtering device and a filtering method

Growing community of inventors

Rostock, Germany

Holger Lantow