Safeguard Biosystems Holdings Ltd.

Micronas Holding Gmbh

Micronas Gmbh

Qfood Gmbh

Endress+hauser Conducta Gesellschaft Fur Mess- Und Regeltechnik Mbh+co. Kg

Ava Lifescience Gmbh

Other

Smaak Maker Holding B.v.

Safeguard Dx Ltd

Klapproth, Holger, Dr.

Rühe, Jürgen

Holger Klapproth

Mirko Lehmann

Ulrich K Sieben

Sonja Bednar

Nicolaas Smit

Ingo Freund

Robert Seidel

Jürgen Rühe

Marc A Kessemeier

Hassan Jumaa

Ulrich Birsner

Johannes Baader

Claas Müller

Marcus Dühren-Von Minden

Joachim Haas

Kevin Boynton

Oswald Prucker

Jonathan E Green

Martina Auerswald

Sonja Mohry

Sonia Mohry

Marc Kessemeier

Keen Yee

The present disclosure provides improved methods for bead beating and a bead beating system useful therefor. The present disclosure further provides methods of using the bead beating system to extract nucleic acids from cells containing the nucleic acids.

Bead beating tube and method for extracting deoxyribonucleic acid and/or ribonucleic acid from microorganisms

The disclosure provides three-dimensional crosslinked polymer networks comprising one or more channels extending from the surface and/or near the surface of the network into the interior of the network, arrays comprising the networks, processes for making the networks, and uses of the networks and arrays.

Three-dimensional polymer networks with channels situated therein

The present disclosure provides improved methods for bead beating and a bead beating system useful therefor. The bead beating system comprises a sample tube, beads, and a dry blocking agent, and methods for using the bead beating system to extract nucleic acids from cells containing the nucleic acids.

The present invention relates to the field of producing, identifying, and selecting biological binding molecules, e.g. in particular antibodies or fragments thereof, which selectively bind to somatically hypermutated B-cell receptors or B-cell receptor complexes. The method is used in order to select a biological binding molecule which specifically binds to a B-cell receptor having hypermutated regions as the target receptor, but not to a B-cell receptor without hypermutated regions, and is carried out in a cell-based system using immature B cells which are in the pro/pre stage and cause a 'Triple Knockout' of the genes for RAG2 or RAG1, Lambda5, and SLP65.

Method for selecting biological binding molecules

The present invention relates to the field of production, identification and selection of biological binding molecules such as antibodies or fragments thereof, as well as to diagnostic procedures using them in the diagnosis of cancers, in particular malignant B-cell neoplasia. The binding molecules are able to selectively bind to autonomously active or autonomously activated B-cell receptors, the autonomously active or autonomously activated B-cell receptors being characterized by the presence of structural domains to which the binding molecule selectively binds and which are responsible for the autonomously active or autonomously activated state of the B-cell receptors.

Diagnostic method

The present invention relates to the field of the production, identification and selection of biological binding molecules such as antibodies or fragments thereof, as well as to their use in the therapy and prophylaxis of cancer diseases, such as, in particular, malignant B-cell neoplasia. The binding molecules are able to selectively bind to autonomously active or autonomously activated B-cell receptors, the autonomously active or autonomously activated B-cell receptors being characterized by the presence of structural domains to which the binding molecule selectively binds and which are responsible for the autonomously active or autonomously activated state of the B-cell receptors.

Biological binding molecule

The disclosure provides three-dimensional cross-linked polymer networks transport channels, arrays comprising the networks, processes for making the networks, and uses of the networks and arrays.

Three-dimensional polymer networks and their use

A sampling device for taking samples from a gaseous beverage under pressure includes a connection for a beverage line, a pump having a pump chamber, a particle filter, a discharging opening for a beverage sample, an outlet for waste, a control device, and a line system connected to the pump chamber with adjustable valves. The sampling device is configured so a beverage sample with a volume smaller than the volume of the pump chamber is introduced from the connection into the pump chamber. The pump chamber is then separated from the connection and is expanded so gas exits from the beverage sample. The pump chamber is then connected to the outlet opening and compressed so gas which has passed out of the beverage sample is displaced. Then, the pump chamber is connected to the discharging opening via the particle filter and compressed so the beverage sample is displaced.

Sampling device for taking beverage samples from a beverage line containing a carbonated beverage under pressure

In a method for monitoring the correspondence of a beer sample with a reference beer, at least 15 reference beer samples of the reference beer are brewed with the same ingredients and the same process parameters. Measurement signals for the absorption spectrum of the reference beer samples are captured and a principal component analysis is carried out for the measurement signals, in which at least 15 principal components are ascertained. A factor loading P(i,j) is respectively determined for each principal component for the individual reference beer samples and a reference value (I) is ascertained, where i denotes the reference beer sample and j denotes the principal component, &#x3bc;(j) refers to the mean value of all factor loadings of the j-th principal component and &#x3c3;(j) refers to the standard deviation of these factor loadings. A reference interval (II) is formed, where n denotes the number of reference beer samples, m denotes the number of principal components, &#x3c3;(j) denotes the standard deviation of all reference values of the j-th principal component and k denotes a constant not equal to zero. A measurement signal is captured for the absorption spectrum of the beer sample and the factor loadings P(i) of this measurement signal are determined for the principal components ascertained for the reference beer samples and a characteristic (III) is formed and compared to the reference interval. Should the characteristic B lie outside of the reference interval, a fault during the production of the beer sample is indicated.

Method for monitoring the correspondence of a beer sample with a reference beer

The disclosure provides an asymmetric PCR amplification method for preparation of single-stranded product and primers and kits useful therefor.

Asymmetric PCR methods, primers and kits

In a method for determining the concentration of glucoraphanin in a plant a sample of the plant is contacted by a polar uncharged organic solvent and comminuted such that glucoraphanin and plant material contained in the sample are dissolved in the solvent and, after removal of undissolved plant parts, the extract formed thereby is subjected to an UV-absorption measurement wherein for a first wavelength range of 200-270 nm, an absorption signal is recorded. A second derivative of the absorption signal is then obtained for a second wavelength range of 240-250 nm and the value of the minimum of the second derivative is determined and, based on this value, a concentration value for the glucoraphanin in the plant is established.

Method for determining the concentration of glucoraphanin and/or sulforaphane in a plant

Growing community of inventors

Freiburg, Germany

Holger Klapproth