Hyglos Invest Gmbh

Hypharm Gmbh

BiomÉrieux Deutschland Gmbh

Biomerieux Sa

Dsm IP Assets B.v.

Profos Ag

Holger Grallert

Stefan Miller

Sonja Molinaro

Roman Meyer

Manfred Biebl

Renate Grassl

Michael Schütz

Michael Forchheim

Bernd Buchberger

Anja Philipp

Johannes Reich

Julia Lorenz

Michael Schuetz

Anna Scherzinger

Sonja Leopoldseder

Julia Kaps

The invention relates to unmasking endotoxins in compositions so that previously present, but undetectable endotoxins are rendered detectable.

Unmasking endotoxins in solution

The present invention relates to assays, kits and oligonucleotides for the detection offor a fast, sensitive and reliable detection ofin a species- and serotype-specific manner. In particular, the present invention provides an assay for the serotype-specific detection of, a kit for the serotype-specific detection of, as well as oligonucleotides useful in such assay or kit. The present invention further relates to the use ofserotype specific antibodies for serotype specific treatment ofinfection in a patient detected for said specificserotype with such an assay or kit.

Chimeric polypeptides and their use in bacterial decolonization

The present invention provides a novel method for the recombinant production of Factor C protein from horseshoe crab using a parasitic protozoan expressing the Factor C protein. In particular, the present invention provides a parasitic protozoan host cell harbouring a polynucleotide encoding horseshoe crab Factor C protein, and a method for producing Factor C protein comprising culturing said parasitic protozoan host cell under conditions such that the cells express the horseshoe crab Factor C protein. Furthermore, the present invention provides recombinant Factor C protein produced by the novel method and its use in the detection and/or removal of endotoxin.

Method for recombinant production of horseshoe crab Factor C protein in protozoa

Method for recombinant production of horseshoe crab factor C protein in protozoa

The present invention relates to chimeric polypeptides comprising a first portion, which comprises a bacteriocin cell wall-binding domain (CBD) and a second portion, which comprises an enzymatic active domain (EAD) selected from the lytic domain of a bacteriophage lysin, a bacteriocin and a bacterial autolysin. Provided are such chimeric polypeptides and variants and fragments thereof, nucleic acids encoding the same, vectors carrying such nucleic acids and host cells transformed or transfected with such vectors. The chimeric polypeptides of the present invention are useful for the reduction of certain bacterial populations, including methods and compositions for the treatment of various bacterial infections. For example, chimeric polypeptides of the present invention have been shown to effectively kill various bacteria, including methicillin-resistant(MRSA), as well as other human pathogens. Thus, provided are compositions comprising chimeric polypeptides according to the present invention, variants or fragments thereof, and the use of such compositions in prophylaxis or therapy of bacterial diseases, bacterial infections or bacterial colonizations.

The present invention provides a novel method for the recombinant production of Factor C protein from horseshoe crab using a parasitic protozoan expressing the Factor C protein. In particular, the present invention provides a parasitic protozoan host cell harboring a polynucleotide encoding horseshoe crab Factor C protein, and a method for producing Factor C protein comprising culturing said parasitic protozoan host cell under conditions such that the cells express the horseshoe crab Factor C protein. Furthermore, the present invention provides recombinant Factor C protein produced by the novel method and its use in the detection and/or removal of endotoxin.

The present invention relates to a novelbacteriophage designated ProCC P825. In particular, the present invention relates to the endolysin PlyP825 encoded by the novel phage ProCC P825 and uses of the novel endolysin PlyP825 for controllingcontamination and infection.

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The present invention relates to bacteriophage tail proteins and the derivatives and fragments thereof that are capable of binding endotoxins in the absence of bivalent positive ions, especially Caor Mg. Further, the present invention relates to methods for depleting endotoxins from solutions and samples using the bacteriophage tail proteins according to the present invention and to a detection method for endotoxins.

Nucleic acids encoding bacteriophage tail proteins

The present invention relates to a novel tail spike protein (TSP) encoded by the novelbacteriophage designated ProCC P825 and uses of the novel TSP for identifying, detecting and monitoring of

The present invention relates to a polypeptide termed ply_pitti26 comprising the sequence as depicted in SEQ ID NO:1 as well as variants of this polypeptide. Furthermore, the present invention relates to nucleic acids and vectors encoding for said polypeptide and variants thereof as well as host cells comprising these nucleic acids and/or vectors. Finally, the present invention relates to the uses of said polypeptide, variants thereof, nucleic acid sequences, vectors and host cells, in particular for the treatment or prophylaxis of a subject infected by or exposed to Staphylococci.

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Wuppertal, Germany

Holger Grallert