Max-planck-gesellschaft Zur F&#xf6;rderung Der Wissenschaften E. V.

Scienion Ag

Biodot, Inc.

Holger Eickhoff

Markus Kalkum

Martin Horn

Thomas C Tisone

Claude Dufresne

Eckhard Nordhoff

Markus Kietzmann

Martin Müller

Holger Rauth

Richard Reinhardt

Christine Lübbert

Martin M&uuml;ller

Christian Wurzel

Rudolf Germer

Thomas Przewieslik

Carsten Arold

Sven Behr

Christoph Heller

Christine Gauss

Eckhardt Nordhoff

Antonin Schenk

Alan Bullock

A method of electron microscopy imaging of samples, using an electron microscope () having a microscope column () and a transfer device () with a grid carriage (), comprises the steps of preparing multiple samples () on a single electron microscopy grid (), including dispensing the samples () with a dispenser device () on distinct positions on the grid (), introducing the grid () with the transfer device () into the microscope column (), and electron microscopy imaging of the samples (), wherein the preparing step includes holding the grid () on the grid carriage () of the transfer device () or on a grid holder device () provided at the electron microscope () and dispensing the samples () on the grid () while holding it on the grid carriage () or on the grid holder device (). Furthermore, an electron microscope () for electron microscopy imaging of samples is described.

Electron microscope and method for transmission electron microscopy imaging of sample arrays

Novel and improved systems and methods for high speed arraying, hybridization, quantitative development and/or assaying are provided. Some embodiments provide a web based arraying format. Some other embodiments provide a sheet based arraying format. Some embodiments use a drop on drop assaying or hybridization mode. In some embodiments, a substantially inert substrate is utilized. In some other embodiments, an interactive substrate is utilized.

Systems and methods for high speed array printing and hybridization

A method for depositing samples, in which at least one sample () is arranged on a substrate (), comprises the following steps: positioning a sample dispenser () above the substrate (), and actuating the sample dispenser () so that the sample () is moved from the sample dispenser () along a trajectory () to a predefined deposition position () on the substrate (), wherein at least part of the trajectory () is shielded against electrical interference fields. Also described is a substrate () for receiving samples (), comprising a substrate body (), on the surface of which at least one deposition position () is provided, and a shielding electrode (), which is designed so as to electrostatically shield the space above the at least one deposition position () against electrical interference fields.

Method and devices for depositing samples on an electrically shielded substrat

The invention relates to a microdispenser () for dispensing a liquid sample in a dispensing device, with a sample container () for receiving the liquid sample, and with a nozzle () for dispensing the sample located in the sample container (). The microdispenser () with the filled sample container () can in this case be stored independently of and fluidically separately from the dispensing device, without the sample escaping from the sample container () during storage.

Microdispenser and associated operating method

For processing of substances in the reservoir () of a microdroplet dosing device (), movement of a solid carrier material with a binding-active surface takes place in the reservoir, and binding of the substance takes place on the surface of the carrier material which comprises magnetic particles () or a carrier pad.

Method and device for processing extremely small substance quantities

A sample taking apparatus comprises a plurality of separation tools () (for example, punching capillaries) on a holding device (), wherein the separation tools () are each provided with actuating means () for separate control thereof. In a sample taking method (for example, for punching samples from separation gels), successively removed samples are deposited in parallel onto a target substrate.

Apparatus and method for taking samples from polymer support material

In an electrophoresis device with numerous separation channels S loadable with samples, samples are loaded by applying samples in a shared injection channel I intersecting the separation channels S near a point where the injection channel I crosses one of the separation channels S. During exposure to a voltage in the injection channel, the samples are transferred to the separation channels S, and there electrophoretically separated.

Device and method for miniaturized, highly parallel electrophoretic separation

A multi-channel dispensing head including a plurality of micropipettes, each micropipette having an electrically actuatable trigger device with a ground and signal terminal; and a shared carrier having a plurality of receptacles located in a one- or two-dimensional arrangement and sized and shaped to receive said micropipettes, each receptacle having a ground and signal contact, wherein the ground and signal contacts on the carrier are spaced apart in the direction of a longitudinal axis extending through the respective micropipettes and each of the ground and signal contacts on the carrier contacting the ground and signal terminals of the trigger devices, respectively.

Device and procedure for the electrically triggered microdrop release with a dispensing head

A procedure for detecting microparticles released by at least one dispenser, encompassing the following steps: (a) triggering the dispenser over an oscillation target ( ) with a sensor material ( ), so that at least one microparticle hits the sensor material ( ) and excites an acoustic wave, (b) detecting the acoustic wave with at least one oscillation sensor ( ) connected with the sensor material ( ), which emits an electrical sensor signal when the acoustic wave arrives, and (c) evaluating the sensor signal to determine the impact of the microparticle. The procedure is aimed at detecting the impact and/or impact positions of microparticles on a target. A detector for executing the procedure is also described.

Growing community of inventors

Berlin, Germany

Holger Eickhoff