Heraeus Precious Metals Gmbh & Co. Kg

Medac Gesellschaft Fur Klinische Spezialpraparate Mbh

Context Biopharma Inc.

Heraeus Deutschland Gmbh & Co Kg

Holger Bindernagel

Tero Kunnari

Stefan Wallert

Sascha Weiser

Andrew Lupton

Stefan Proniuk

Holger Rauter

Silvia Werner

Ulf Tilstam

Steffen Jost

Methods and systems for making intermediates in the synthesis of onapristone are provided. Aspects include the photoconversion of onapristone synthesis intermediates using a narrow band frequency light source.

Methods of making onapristone intermediates

A method for purifying epidaunorubicin is provided. The purification method involves the removal of the impurity epi-feudomycin, which is formed as a by-product in the biotechnological production of epidaunorubicin.

Purification of epidaunorubicin

4'-epidaunorubicin hydrochloride is provided in a crystalline form which is stable and readily soluble. A process of producing the crystalline form includes crystallizing 4&#x2032;-epidaunorubicin hydrochloride in a solvent system including (a) solvent A selected from Cand Chalogenated solvents and mixtures thereof, (b) solvent B selected from C-Cstraight and branched alcohols and mixtures thereof, and (c) solvent C selected from C-Cstraight and branched alcohols and mixtures thereof, wherein solvent C is selected to provide lower solubility to 4&#x2032;-epidaunorubicin hydrochloride than solvent B. A method of producing an anthracycline using crystalline 4&#x2032;-epidaunorubicin hydrochloride is also provided.

Crystalline 4'-epidaunorubicin hydrochloride and use thereof

4'-epidaunorubicin hydrochloride is provided in a crystalline form which is stable and readily soluble. A process of producing the crystalline form includes crystallizing 4&#x2032;-epidaunorubicin hydrochloride in a solvent system including (a) solvent A selected from Cand Chalogenated solvents and mixtures thereof, (b) solvent B selected from C-Cstraight and branched alcohols and mixtures thereof, and (c) solvent C selected from C-Cstraight and branched alcohols and mixtures thereof, wherein solvent C is selected to provide lower solubility to 4&#x2032;-epidaunorubicin hydrochloride than solvent B.

Crystallization of 4'-epidaunorubicin hydrochloride

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Gelnhausen, Germany

Holger Bindernagel