Flagship Pioneering Innovations Vi, LLC

Hok Hei Tam

Barry Andrew Martin

Maria Helena Christine Van Rooijen

Nataliya Vladimirovna Nukolova

Yajie Niu

Ignacio Martinez

Daniel Garcia Cabanillas

Maier Steve Avendaño Amado

Piotr Stanislaw Kowalski

Simon Schwizer

John Patrick Casey, Jr

David Barry Kolesky

Michael Ka Chun Wong

Siddharth Dilipkumar Patel

Roman Lvovitch Bogorad

Disclosed herein are plant-modifying compositions including a plurality of plant messenger packs (PMPs) (e.g., including a plant extracellular vesicle (EV), or segment, portion, or extract thereof), wherein the PMPs include a plant-modifying agent, and wherein the plant-modifying agent comprising the heterologous RNA. The compositions herein are useful in methods for modifying plants such as to increase plant fitness, wherein the increase in plant fitness comprising an increase in development, growth, yield, resistance to abiotic stressors, or resistance to biotic stressors.

Methods and compositions for the modification of plants

Disclosed herein are compositions including a plurality of plant messenger packs, (e.g., including a plant extracellular vesicle (EV), or segment, portion, or extract thereof), that are modified to have enhanced cell uptake (e.g., animal plant cell uptake, bacterial cell uptake, or fungal cell uptake), e.g., for use in a variety of agricultural or therapeutic methods.

Modification of plant messenger packs with charged lipids

Disclosed herein are methods, and related bioreactors, for manufacturing plant messenger packs (PMPs), which can be formulated for use in a variety of agricultural and therapeutic methods.

Methods for manufacturing plant messenger packs

Disclosed herein are agricultural compositions comprising plant messenger packs (PMPs), methods for using the same, and methods and related bioreactors for manufacturing PMPs.

Agricultural compositions and related methods

The present disclosure relates to therapeutic agents and combinations thereof (e.g., pharmaceutical compositions) for the treatment of a viral infection in a subject, tissue or cell.

Combination therapies for the treatment of viral infections

Growing community of inventors

Newton, MA, United States of America

Hok Hei Tam