University of California

The University of Arizona

Hoda Anton-Culver

Eugene W Gerner

Frank L Meyskens

Christine E McLaren

Jason A Zell

Patricia Thompson

Particia A Thompson

Jason Zell

Christine Mclaren

Patricia A Thompson

Eugene Gerner

The present invention provides methods and kits a) for predicting colorectal cancer patient survival, as well as the survival of patients harboring other invasive cancers where cellular proliferation and carcinogenesis is linked, in part, to high levels of ODC activity and increased cellular polyamine contents, and b) for selecting the corresponding treatment options for such patients based on the allelic nucleotide sequence or SNP at position +316 of the ODC1 promoter gene as well as cancer treatment methods, in each case, which include the determination of the ODC1 promoter +316 position genotype, as a means to guide treatment selection.

Carcinoma diagnosis and treatment, based on ODC1 genotype

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Irvine, CA, United States of America

Hoda Anton-Culver