The UAB Research Foundation (The University of Alabama at Birmingham)

Yonsei University

Emory University

The Uab Foundation

Ho-Wook Jun

Young-Sup Yoon

Peter Anderson

Shin-Jeong Lee

Ajay Tambralli

Meenakshi Kushawaha

Bryan Adam Blakeney

Brigitta C Brott

Derrick Dean

Brigitta Brott

This disclosure relates to methods of generating endothelial cells derived from stem cells. In certain embodiments, the cells are useful for inducing vasculature in muscles and cardiac tissue. In certain embodiments, the disclosure relates to methods of transforming pluripotent or multipotent stem cells, such as embryonic or induced pluripotent stem cells, into endothelial cells derived therefrom using a GSK3 inhibitor and/or delta like canonical notch ligand 4 (DLL4).

Method of producing stem cell-derived endothelial cells and uses thereof

Disclosed herein are peptide amphiphiles for use in producing a natural endothelium mimicking nanomatrix. The disclosed natural endothelium mimicking nanomatrix can be used to coat medical devices such as vascular stents to promote endothelializaiton and inhibit restenosis and thrombosis. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Endothelium mimicking nanomatrix

Embodiments of the present disclosure provide electrospinning devices, methods of use, uncompressed fibrous mesh, and the like, are disclosed.

Electrospinning apparatus, methods of use, and uncompressed fibrous mesh

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Hoover, AL, United States of America

Ho-Wook Jun