Hanmi Pharm. Co., Ltd.

Hanmi Science Co., Ltd.

Ho Seok Kim

Kwee Hyun Suh

Young Gil Ahn

In Hwan Bae

Ji Young Song

Eun Young Byun

Seung Ah Jun

Tae Hee Ha

Jung Beom Son

Eun Joo Kwak

Jae Hyuk Jung

Jong Ouk Baek

Sang Mi Han

Maeng Sup Kim

Seung Hyun Jung

Young Hee Jung

Hae Kyoung Ju

Mi Yon Shim

Provided are a thieno[3,2-d]pyrimidine derivative of formula (I) or a pharmaceutically acceptable salt thereof having inhibitory activity for protein kinase, and a pharmaceutical composition comprising same for prevention and treatment of abnormal cell growth diseases.

Thieno[3,2-D]pyrimidine derivatives having inhibitory activity for protein kinases

A method for preparing a thienopyrimidine compound of Formula 1, which is a selective inhibitor of tyrosine kinase activity, in particular, of mutant epidermal growth factor receptor tyrosine kinase. Intermediates used in the method are provided.

Method for preparing thienopyrimidine compound and intermediates used therein

The present invention provides a novel method for preparing a thienopyrimidine compound of Formula 1, which is a selective inhibitor of tyrosine kinase activity, in particular, of mutant epidermal growth factor receptor tyrosine kinase, and novel intermediates used in the method.

Provided is a pharmaceutical composition comprising, as an active ingredient, a quinoline or quinazoline derivative of formula (I), a pharmaceutically acceptable salt, an isomer, a hydrate, and a solvate thereof, which is effective in the prevention and treatment of a cancer, inflammation, autoimmune diseases or neurodegenerative disorders which are induced by the overexpression of inhibitor of apoptosis proteins (IAPs).

Quinoline or quinazoline derivatives with apoptosis inducing activity on cells

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Jeonju-si, South Korea

Ho Seok Kim