The Chinese University of Hong Kong

City University of Hong Kong

Nanyang Technological University

The Hospital Authority

Ho Pui Ho

Shu Yuen Wu

Siu Kai Kong

Chinlon Lin

Chi-Man Lawrence Wu

Yick Keung Suen

Chi Lok Wong

Wing Cheung Law

Siu Pang Ng

To Ngai

Kuan Ting Lin

Ping Shum

Ho Chin Kwok

Siu-pang Ng

Siu Chun Ng

Wing Wai Wong

Yi-Ping Ho

Sebastian Beyer

Shu Yeun Wu

Guangyao Cheng

Jun Qiang Zhou

Kwong Chun Lo

Lawrence Chi-man Wu

Alice Kar Lai Yang

Yiu Wa Kwan

Patrick Kwok Leung Kwan

Qiu Lan Chen

Fluorinated metal nanoparticles (f-MNPs) are metal nanoparticles and/or semiconductor nanoparticles having a plurality of fluorinated alkyl ligands attached to the surfaces of the nanoparticles where the f-MNPs are greater than 20 nm in cross-section. The f-MNPs can be used as a surfactant to form active f-MNPs stabilized aqueous droplet, which can be used in a light-mediated microfluidic device where droplet movement, merging, splitting, and sorting can be carried out as directed by one or more laser beams focused onto one or more spots of light-mediated microfluidic device.

Light-mediated manipulation of droplets stabilized by fluorinated nanoparticles with photothermal effect

A microfluidic platform including a microfluidic layer and a contact layer. The microfluidic layer is embedded with a microfluidic structure including a micro-channel and a fluidic sample contained in the micro-channel. The contact layer is able to be attached to the microfluidic layer, and includes a first heater for heating a first area of the microfluidic structure to a first temperature and a second heater for heating a second area of the microfluidic structure to a second temperature. The microfluidic layer and the contact layer rotate together during operation. A method for controlling a sample in the micro-channel of the microfluidic structure.

Microfluidic platform and method for controlling the same

An optical sensing apparatus and a method for detecting characteristics of a sample.

Optical sensing apparatus and a method for detecting characteristics of a sample

Disclosed are optical sensing devices and methods for detecting samples using the same. The optical sensing device comprises a source unit configured to generate a polychromatic light beam containing p-polarized and s-polarized components; an interferometric unit configured to split the light beam into a probe beam passing a first path and a reference beam passing a second path and to recombine the probe beam output from the first path and the reference beam output from the second path; a sensing unit disposed in the first path to introduce a first SPR effect associated with a target sample to the probe beam; and a detection unit configured to detect target sample characteristics by obtaining an intensity spectrum of the recombined light beam. The introduction of a polychromatic light source in the optical sensing device increases the detection dynamic range and the detection sensitivity.

Optical sensing devices and methods for detecting samples using the same

An optical sensing device including a source unit configured to generate a polychromatic light beam containing p-polarized beam and s-polarized beam; an interferometric unit configured to introduce birefringent retardation for generating optical path difference between the p-polarized beam and the s-polarized beam; a SPR sensing unit configured to receive both p-polarized beam and s-polarized beam and induce a SPR effect to the p-polarized beam associated with a target sample; and a detection unit for detecting target sample characteristics by obtaining an interference spectrum of the p-polarized beam and the s-polarized beam from the SPR sensing unit.

There is disclosed a phase sensitive surface plasmon resonance sensing apparatus wherein a testing beam may be reflected from a sensing surface at a plurality of angles. There are also disclosed methods for surface plasmon resonance sensing.

Method and apparatus for phase sensitive surface plasmon resonance

Disclosed is an optical sensing device including a source unit providing a beam of light with continuously modulated phase retardation between p- and s-polarization components of the light by employing a LCM; a reference unit receiving a first part of the light to provide a reference signal; a SPR sensing unit receiving a second part of the light to induce a phase retardation change between the p- and s-polarization components due to SPR associated with a sample; a probe unit receiving the light after SPR to provide a probe signal; and a detection unit connected to the reference unit and the probe unit to detect characteristics of the sample by comparing the reference signal with the probe signal. By using active phase modulation technologies and differential phase measurement, it is possible to fulfill chemical and biological detection.

Surface plasmon resonance sensors and methods for detecting samples using the same

Disclosed is an optical sensing device, which comprises a light source emitting a light; a beam splitter; an SPR sensor unit comprising a sensing surface; and a detecting mechanism; and a converting unit converting the first beam and the second beam from the optical device into a two-dimensional interference fringe pattern. From the above-mentioned configuration, an extra phase shift of a detection beam in SPR phase measurement is obtained. The differential measurement approach has shown to achieve a sensitivity figure significantly better than the best result that can be obtained from the prior art in the field of the measurement based on an SPR sensor.

Optical sensing devices with SPR sensors based on differential phase interrogation and measuring method using the same

Surface plasmon resonance sensors and method for detecting samples using the same

Growing community of inventors

Hong Kong, China

Ho Pui Ho