Korea Institute of Bioscience and Biotechnology

Korea Research Institute of Bioscience and Biotechnology

Ho-Jae Lee

Soo Hyun Kim

Sei-Ryang Oh

Doo-Young Kim

Jung Weon Lee

Jung-hee Kim

Sangku Lee

Joongku Lee

Hyeong-Kyu Lee

Soon-Ja Choi

Su-Yong Choi

Eun-Ah Kim

Kyungseop Ahn

Jung-Hee Kim

The present invention relates to an anoikis-inducing agent comprising aextract, a tiarellic acid compound isolated therefrom or a pharmaceutically acceptable salt thereof, which is specific to cancer cells expressing a tumor-associated antigen L6 or a homolog thereof. Theextract, the tiarellic acid compound isolated therefrom or pharmaceutically acceptable salt thereof of the present invention leads to loss of cell adhesion to reduce cancer cell proliferation and exhibits the effect of inducing cell death in cancer cells expressing a tumor-associated antigen L6 or a homolog thereof, thereby being used for preventing and treating cancer diseases due to a tumor-associated antigen L6 or a homolog thereof.

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Daejeon, South Korea

Ho-Jae Lee