A/s Dumex (dumex Ltd)

Dumex-alpharma A/s

Hjarne Dyrsting

Torben Koch

Dan Jorgensen

It has been found that sugar acid salts represent beneficial controlled release forms for basic organic drug compounds. Examples of appropriate salts include mono, di, oligo and polysaccharide poly-O-sulphonic acid salts of antibiotics such as tetracyclins and aminoglycosides.

Drug salts

The present invention relates to novel amino glycoside salts of sucrose-octa-O-sulfonic acid of formula I:

Salts of amino glycosides

A salt of sucrose-octa-O-sulfonic acid and a tetracycline useful in inhibiting protein synthesis of bacteria.

Salts of tetracyclines

Fluorosubstituted benzaldehydes are condensed with anisil and ammonium acetate to yield the corresponding 2-(fluorosubstituted phenyl)-4,5-bis(4-methoxyphenyl)imidazoles. Alternatively fluorosubstituted benzaldehydes are condensed with anisil monoxime and ammonium acetate to yield the corresponding 2-(fluorosubstituted phenyl)-4,5-bis(4-methoxyphenyl)-imidazole-3-oxides which can subsequently be reduced to yield the corresponding 2-(fluorosubstituted phenyl)-4,5-bis(4-methoxyphenyl)imidazoles. These imidazoles have interesting pharmacological properties.

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Virum, Denmark

Hjarne Dyrsting