Sumitomo Dainippon Pharma Co., Ltd.

The Kitasato Institute

Sumitomo Pharma Co., Ltd.

Hitoshi Suda

Toshiaki Sunazuka

Yohei Ikuma

Toshio Kanai

Sachiko Koike

Shingo Mizushima

Shunichiro Uesugi

Yoshihiko Noguchi

Takayuki Fukaya

Yuki Mizukami

Izumi Sasaki

Yoshihiro Horiuchi

Hiroaki Fujiwara

Kiyoto Sawamura

Mitsutaka Iwata

Provided is a novel compound that has an excellent &#x3b2;-lactamase inhibitory effect. More specifically, provided is a compound represented by formula (1a), (1b) or (11) having an excellent &#x3b2;-lactamase inhibitory effect or a pharmaceutically acceptable salt thereof. By using this compound either in combination with a &#x3b2;-lactam drug or alone, a useful preventive or therapeutic agent for bacterial infections is provided. Also provided are useful preventive or therapeutic agents for treating various diseases with the combined use of the aforesaid compound and &#x3b2;-lactam drugs.

Oxo-substituted compound

Provided is a compound represented by formula (1) or a pharmacologically acceptable salt thereof. (In the formula, A is Carylene, etc.; R, Rand Reach independently is a hydrogen atom, a halogen atom, a Calkyl group, a Calkoxy group, etc.; Ris an optionally substituted Caryl group, an optionally substituted 5- to 12-membered monocyclic or polycyclic heteroaryl group, an optionally substituted Caralkyl group, etc.; m is 0, etc.; n is an integer of 0 to 2.) 

Cyclic amide derivative

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Osaka, Japan

Hitoshi Suda