Fujisawa Pharmaceutical Company, Ltd.

Hitoshi Sawada

Hiroshi Kayakiri

Noritsugu Yamasaki

Takafumi Imoto

Takahiro Hiramura

Teruo Kyoto Oku

Yoshito Abe

Hiroyuki Setoi

Hitoshi Hamashima

Masahiro Nishikawa

Osamu Onomura

Tatsuya Zenkoh

Takehiko Ohkawa

Naoki Ishibashi

Yuki Sawada

Tsuyoshi Mizutani

Noriko Oku

Hirokazu Tanaka

Keiji Hemmi

Masayoshi Murata

Kentaro Sato

Masahiro Neya

Chiyoshi Kasahara

Tomohiro Oku

Miho Kawauchi

Akira Katayama

Noriko Oku, Legal Representative

Chikaka Oku

Chikako Oku, Legal Representative

Chikako Oku

Tomohito Oku, Legal Representative

Tomohito Oku

Imidazole compounds represented by general formula (I): wherein each symbol is as defined in the specification, and salts thereof, and a pharmaceutical composition containing same are provided. These compounds are useful in treating the diseases curable based on a hypoglycemic action, and the diseases curable based on a cGMP-PDE inhibitory action, a smooth muscle relaxing action, a bronchodilating action, a vasodilating action, a smooth muscle cell inhibitory action and an allergy inhibitory action.

Imidazole compounds and medicinal use thereof

A sulfonamide compound of the formula (I):R&#x2014;SONHCO&#x2014;A&#x2014;X&#x2014;R&#x2003;&#x2003;(I)wherein Ris alky, alkenyl, alkynyl and the like; A is an optionally substitutedheteropolycyclic group except benzimidazolyl, indolyl, 4,7-dihydrobenzimidazolyland 2,3-dihydrobenzoxazinyl; X is alkylene, oxa, oxa(lower)alkylene and the like; and Ris optionally substituted aryl, substituted biphenylyl and the like, a salt thereof and a pharmaceutical composition comprising the same. The sulfonamide compound is effective for the diseases treatable based on their blood sugar level-depressing activity, cGMP-PDE (especially PDE-V)-inhibiting activity, smooth muscle relaxing activity, bronchodilating activity, vasodilating activity, smooth muscle cell suppressing activity, and antiallergic activity.

Sulfonamide compounds and pharmaceutical use thereof

The present invention relates to a sulfonamide compound of the formula (I):wherein each symbol is as defined in the specification, a salt thereof, and a pharmaceutical composition containing same. This compound can be an effective agent for the prophylaxis and treatment of the diseases curable based on a hypoglycemic action, and the diseases curable based on a cGMP-PDE inhibitory action, a smooth muscle relaxing action, a bronchodilating action, a vasodilating action, a smooth muscle cell inhibitory action and an allergy suppressing action.

Sulfonamide compounds and uses thereof as medicines

The present invention provides novel benzimidazole derivatives of the following formula (I) and salts thereof:wherein Rrepresents a lower alkyl group or a lower alkyloxy-lower alkyl group; Rrepresents a hydrogen atom, a halogen atom, an alkyl group having 1 to 8 carbon atoms, an aryl group, and such; Rrepresents a lower alkyl group, a lower alkenyl group, an aryl group, a lower alkylaryl group, an aryl-lower alkenyl group, a halothienyl group, a lower alkylamino group, or an aryl-lower alkylamino group; A represents a benzene ring, a naphthalene ring, or a pyridine ring; and X represents a halogen atom. The derivatives and their salts have blood sugar level-depressing activity or PDE5-inhibiting activity, and are useful as pharmaceutical preparations.

Benzimidazole derivatives

Sulfonamide compounds and medicinal use thereof

This invention relates to new benzamide derivatives having a vasopressin antagonistic activity, etc. and represented by general formula (I):

Benzamide derivatives having a vasopressin antagonistic activity

Novel aromatic ring derivatives represented by formula (I) or their pharmaceutical acceptable salts are provided.

Aromatic ring derivatives

Endothelin antagonists

Benzamide derivatives and their use as vasopressin antagonists

Growing community of inventors

Ibaraki, Japan

Hitoshi Sawada