Kowa Company Limited

Fuji Chemical Industries Co., Ltd.

Hitoshi Sakai

Kazuhiro Onogi

Hiroshi Kawaguchi

Masayuki Masumoto

Jyunji Katsuyama

Koji Hoda

Teppei Shibata

Tadashi Fukami

Tadashi Yoshigai

Tatsuki Ueno

Yo Nakashima

Tetsuya Oonuki

A silica that is superior in terms of fluidity, oil absorption ability, and compression moldability to conventional silica used as a pharmaceutical additive, and is suitable as an additive for formulations such as pharmaceuticals. A porous silica particle composition having the following properties: (1) a BET specific surface area from 250 to 1,000 m/g; (2) an average particle diameter from 1 to 150 μm; (3) a pore volume from 0.1 to 8.0 cm/g; and (4) an oil absorption capacity from 2.2 to 5.0 mL/g.

Porous silica particle composition

To provide an effective and simple process for producing 4-fluoroisoquinoline-5-sulfonylhalide or a salt thereof, and a simple method for separating for purification of the product from a by-produced position isomer thereof. The process for producing 4-fluoroisoquinoline-5-sulfonyl halide or a salt thereof, characterized in that the process includes reacting 4-fluoroisoquinoline or a salt thereof with sulfuric anhydride in the presence or absence of sulfuric acid, to thereby form 4-fluoroisoquinoline-5-sulfonic acid or a salt thereof, and, subsequently, reacting the formed sulfonic acid compound with a halogenating reagent.

Process for production of 4-fluoroisoquinoline-5-sulfonyl halide or salt thereof

Growing community of inventors

Nakaniikawa-gun, Japan

Hitoshi Sakai