Yamanouchi Pharmaceutical Company Ltd.

Niigata Engineering Co., Ltd.

Hitoshi Nagaoka

Toshinari Tamura

Shin-ichi Tsukamoto

Shinji Usuda

Masatomi Harada

Takeshi Suzuki

Toshiyasu Mase

Hiroyuki Shimizu

Kenichi Tomioka

Hiromu Hara

Takumi Takahashi

Toshimitsu Yamada

Keizo Nakashima

Hiroshi Kanno

A titanium nitride film forming method employing an ion-plating method to produce good decorative properties, to a titanium nitride film forming method which can maintain the stability of the color tone even under high temperatures, and to the vessel obtained through the above methods. The titanium nitride film-forming method used in the present invention is; (1) a titanium nitride film-forming method wherein a titanium nitride film is formed over the surface of a substrate by either the physical metalizing method or the chemical metalizing method, (2) a titanium nitride film-forming method wherein a titanium nitride film is formed over the surface of a substrate, and the substrate is, then, heated in a mixed atmosphere of oxygen and nitrogen, thereby forming a transparent and stable titanium oxide film over the surface of the titanium nitride film, and (3) the titanium nitride film forming method wherein a titanium nitride film is formed over the surface of a substrate, and the substrate is, then, heated in an nitrogen atmosphere, thereby effecting a color tone stabilizing treatment which diffuses nitrogen into the titanium nitride film. The respective titanium nitride film-forming methods are used to provide a vessel manufactured by forming the titanium nitride film over the surface of the vessel's substrate.

Method for forming titanium nitride film and vessel coated by same

Hydrochloride salts of heterocyclic spiro compounds are provided and can be represented by the following general formula: ##STR1## wherein A represents piperidine or N alkyl piperidine or N alkylene attached to a non adjacent piperidine ring carbon, X is S or O, Y is carbonyl, thiocarbonyl, methylene, R.sup.5 methylene, ##STR2## alk in which R.sup.1 to R.sub.3,R.sub.6,R.sub.7 are H or alkyl, R.sub.4 is H, alkyl, COOH, or ester, or --C alkyl, R.sub.5 is halo, OH,SH, O alkyl, S alkyl, O acyl or S acyl, and Z, and Z.sub.2 are O or S. The above compounds act upon muscarinic acetylcholine receptors, thereby activating the acetylcholine nervous functions in the central nervous system.

Hydrochloride salts of heterocyclic spiro compounds

The lid of a box is pushed up from the main body of the box by injecting gas by use of one or more injection nozzles into a gap formed between the lid and main body of the box and then, with part of a top plate of the lid in contact with a lid rotating stopper, gas is further injected into the gap, or the lid is pushed up by injecting gas into the gap by use of one or more lower position injection nozzles and then gas is injected into the gap by use of one or more higher position injection nozzles in one or more stages, before the lid is opened from the main body. Thereby, it is possible to prevent the lids from being opened in a three-dimensional inclined state (in a one-side opened state) as well as to prevent the lid and main body of a box from being pushed upwardly simultaneously.

Method and apparatus for opening lid of box

Heterocyclic spiro compounds represented by the following general formula and salts thereof: ##STR1## wherein A represents piperidine or N alkyl piperidine or N alkylene attached to a non adjacent piperidine ring carbon, X is S or O, Y is carbonyl, thiocarbonyl, methylene, R.sup.5 methylene, ##STR2## in which R.sup.1 to R.sub.3, R.sub.6, R.sub.7 are H or alkyl, R.sub.4 is H, alkyl, --COOH, or ester, or ##STR3## R.sub.5 is halo, OH, SH, O alkyl, S alkyl, O acyl or S acyl, and Z.sub.1 and Z.sub.2 are O or S. The above compounds act upon muscarinic acetylcholine receptors, thereby activating the acetylcholine nervous functions in the central nervous system.

Heterocyclic spiro compounds and methods for preparing the same

Heterocyclic spiro compounds represented by the following general formula and salts thereof ##STR1## The above compounds act upon muscarinic acetylcholine receptors, thereby activating the acetylcholine nervous functions in the central nervous system.

A saturated heterocyclic carboxamide derivative of the following general formula (I) and salts thereof which have platelet activating factor (PAF) antagonizing activity. ##STR1##

Saturated heterocyclic carboxamide derivatives

Heterocyclic spiro compounds represented by the following general formula and salts thereof: ##STR1## The above compounds act upon muscarinic acetylcholine receptors, thereby activating the acetylcholine nervous functions in the central nervous system.

Growing community of inventors

Tokyo, Japan

Hitoshi Nagaoka