Shionogi Company Limited

Viiv Healthcare Company

Hitoshi Murai

Hidenori Mikamiyama

Masahiro Fuji

Noriyuki Kurose

Hiroshi Yoshida

Brian Alvin Johns

Takeshi Endo

Jason Gordon Weatherhead

Ronald George Sherrill

Teruhiko Taishi

Eric Eugene Boros

Cecilia Suarez Koble

Takshi Kawasuji

The present invention features compounds that are HIV integrase inhibitors and therefore are useful in the inhibition of HIV replication, the prevention and/or treatment of infection by HIV, and in the treatment of AIDS and/or ARC.

2-oxonaphthyridine-3-carboxamides HIV integrase inhibitors

A compound of the formula (I): wherein Z, Zand Zeach is independently carbon atom or nitrogen atom; Y is hydroxy, mercapto or amino; Ris a group of the formula: (wherein C ring is nitrogen-containing heteroaryl) has an inhibitory activity against integrase.

Nitrogen-containing heteroaryl compounds having inhibitory activity against HIV integrase

A heterocyclic compound of the formula (I): wherein Bis &#x2014;C(R)&#x2550; or &#x2014;N&#x2550;; R' is H, etc.; one of Rand Ris -Z-Z-Z-Rwherein Zand Zare independently single bond, optionally substituted alkylene, etc.; Zis single bond, optionally substituted alkylene, etc.; Ris optionally substituted aryl, optionally substituted heteroaryl, etc., and the other of Rand Ris H; -A- is &#x2014;C(&#x2014;Y)&#x2550;C(&#x2014;R)&#x2014;C(&#x2014;R)&#x2550;C(&#x2014;R)&#x2014;, etc. wherein Y is OH, etc.; Ris &#x2014;CORwherein Ris OH, etc.; one of Rand Ris carboxy, etc., and the other of Rand Ris H, etc,a prodrug thereof, a pharmaceutically acceptable salt thereof, and a solvate thereof, having an antiviral activity, more particularly, an inhibitory activity against HIV integrase, and a pharmaceutical composition containing the same, especially an anti-HIV drug.

Heterocyclic compounds having inhibitory activity against HIV integrase

Nitrogen-containing heteroaryl compounds having HIV integrase inhibitory activity

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Osaka, Japan

Hitoshi Murai