Nikon Corporation

Yamanouchi Pharmaceutical Company Ltd.

Astellas Pharma Gmbh

Hitoshi Kawai

Akira Tokuhisa

Shunsuke Watanabe

Tetsuya Tamura

Takao Mizumoto

Muneo Fukui

Tatsuya Takahashi

Masataka Katsuma

Atushi Kajiyama

Jun Kawakami

Hiroshi Kitano

Yoshinori Oshita

Yuki Kasashima

Akira Ishida

Kouichi Tsukihara

Ippei Kurimoto

A laser light source device, comprising M number of laser light sources, of which frequency is shifted from a fundamental frequency by (m&#x2212;1)&#xb7;a&#xb7;&#x394;&#x3c9;, a first laser light source sectionand a first fiber amplifier sectionfor amplifying these laser lights, a first optical multiplexerfor approximately coaxially superimposing the laser lights emitted from the first fiber amplifier sectionand emitting the laser lights, a first wavelength conversion devicefor multiplying the frequency of the laser lights emitted from the first optical multiplexerby A, M number of laser light sources, of which frequency is shifted from the fundamental frequency by (m&#x2212;1)&#xb7;b&#xb7;&#x394;&#x3c9;, a second laser light source sectionand a second fiber amplifier sectionfor amplifying these laser lights, a second optical multiplexerfor approximately coaxially superimposing the laser lights emitted from the second fiber amplifier sectionand emitting the laser lights, a second wavelength conversion devicefor multiplying the frequency of the laser lights emitted from the second optical multiplexerby B, and a third wavelength conversion devicefor simultaneously receiving the laser lights emitted from the first and second wavelength conversion devicesandand converting the laser lights into laser lights, of which frequency is (A+B) times the fundamental frequency, the laser light source devicebeing characterized in that the expression A&#xb7;a+B&#xb7;b=0 is satisfied.

Laser light source device, exposure device, and mask inspection device using this laser light source device

Regarding an object of sufficient suppression of unpleasant taste in the oral cavity and quick dissolution in the gastrointestinal tract, which is generated when a drug having a strong unpleasant taste such as bitterness, astringency and the like is applied to a quickly disintegrating preparations in the oral cavity, this invention has achieved the aforementioned object for the first time by employing a constitution of coating a coat of a water-soluble polymer and a specified ratio of a pH-independent water-insoluble polymer and hydroxypropylcellulose.

Coated fine particles containing drug for intrabuccally fast disintegrating dosage forms

A fifth harmonic wave is formed from a fundamental wave of p-polarized light via a second harmonic wave forming optical element, a third harmonic wave forming optical element, and a fifth harmonic wave forming optical elementand a second harmonic wave of p-polarized light is formed from a fundamental wave of s-polarized light by a second harmonic wave forming optical element. The fifth harmonic wave of p-polarized light that is subjected to beam shaping by cylindrical lensesand, the fundamental wave of s-polarized light, and the second harmonic wave of p-polarized light are combined by a dichroic mirror, and are incident on a seventh harmonic wave forming optical element. Furthermore, a seventh harmonic wave of s-polarized light is formed from the second harmonic wave and fifth harmonic wave of p-polarized light, and this seventh harmonic wave is mixed with the fundamental wave of s-polarized light in an eighth harmonic wave forming optical element, so that an eighth harmonic wave of p-polarized light is formed. As a result, an eighth harmonic wave can be formed in a simpler optical system than a conventional optical system.

Wavelength converting optical system, laser light source, exposure apparatus, mask examining apparatus, and macromolecular crystal lens machining device

In nonlinear optical crystalD, each step of wavelength conversion can be performed using another fundamental wave that is output from light output unit, without using the fundamental wave whose output level has been attenuated after going through wavelength conversion for several steps (wavelength conversion in nonlinear optical crystalsA toC). Therefore, the wavelength conversion efficiency improves and the peak power of optical amplifiersandcan be suppressed, which allows the wavelength of lights that are output from optical amplifiersandto be further narrowed.

Light source unit and light irradiation unit

The present invention pertains to a quick disintegrating tablet in buccal cavity, characterized in that drug-containing particles with a mean particle diameter of approximately 50 to approximately 250 &#x3bc;m and an apparent specific gravity of approximately 0.5 to approximately 1.2 consisting of a bitter tasting drug and/or drug of inferior fluidity and a pharmaceutical preparation carrier and obtained by spray drying are added to a quick disintegrating tablet in buccal cavity comprising a drug and a saccharide. Moreover, the present invention pertains to a method for manufacturing drug-containing particles having a specific mean particle diameter and specific apparent gravity by dissolving and suspending a bitter tasting drug and/or drug of inferior fluidity and a pharmaceutical preparation carrier to a high concentration in terms of solid concentration in a solvent and spray drying this liquid and a method for manufacturing a quick disintegrating tablet in buccal cavity comprising the particles.

Quick disintegrating tablet in buccal cavity and manufacturing method thereof

The present invention pertains to a quick disintegrating tablet in buccal cavity, characterized in that drug-containing particles with a mean particle diameter of approximately 50&tilde;approximately 250 &mgr;m and an apparent specific gravity of approximately 0.5&tilde;approximately 1.2 consisting of a bitter tasting drug and/or drug of inferior fluidity and a pharmaceutical preparation carrier and obtained by spray drying are added to a quick disintegrating tablet in buccal cavity comprising a drug and saccharide. Moreover, the present invention pertains to a method for manufacturing drug-containing particles having a specific mean particle diameter and specific apparent gravity by dissolving and suspending a bitter tasting drug and/or drug of inferior fluidity and a pharmaceutical preparation carrier (preferably containing water-insoluble polymer, particularly at least aqueous ethyl cellulose suspension (preferably containing plasticizer)) to a high concentration in terms of solid concentration in a solvent that is pharmaceutically acceptable and then spray drying this liquid using a rotating disk-type spray dryer, with the disk operating at low speed, and a method for manufacturing a quick disintegrating tablet in buccal cavity comprising said particles.

Colon-specific drug release system

A second harmonic generation (SHG) device is used for conversion of wavelength. The direction of polarization of light beams is suitably rotated by a direction-of-polarization rotating unit, for example by 45.degree., and thereafter these light beams are guided into the SHG device. This can minimize attenuation of intensity of light beam due to conversion of wavelength. Hence, using this direction-of-polarization rotating unit in the apparatus for measuring the medium, the intensity of light being incident upon the photodetector can be increased, whereby the refractive index of the medium can be measured more accurately than by the conventional apparatus.

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Saitama, Japan

Hitoshi Kawai