Nisshin Flour Milling Co., Ltd.

Kyorin Pharmaceutical Co., Ltd.

Nisshin Pharma Inc.

Hitoshi Inoue

Toshihiro Takahashi

Masashi Suzuki

Koichi Nakamaru

Masanori Sugita

Masato Horigome

Hiroyuki Yamazaki

Masao Nagase

Kenichi Momose

Chikako Suzuki

Shinji Nagai

Kouichi Katsuyama

Yoshiyuki Tahara

Makoto Yanai

Norio Oshida

Kohei Inomata

Takao Kishiye

Tsutomu Takasawa

Kouji Kawamura

Hiroyuki Ikemoto

Reiko Kubota

Hiroyasu Koyama

Noriyoshi Sueda

Koji Kawamura

Nobuhiro Kinoshita

Shigeo Kawase

Tatsuya Ohwaki

Hiroki Kato

Hirohiko Komatsu

Takuya Kishimoto

Ryuuta Fukutomi

Rie Shibayama

Kazuko Kojima

Kouichirou Hagihara

Masako Yamada

There are provided novel 4(2-furoyl)aminopiperidines represented by the general formula (I), their synthetic intermediates, processes for their preparation and medicaments containing them. In the above formula, X is OH or N, and Y is a group of the following general formula (II), formula (II-a) or formula (III):  The 4-(2-furoyl)aminopiperidine derivatives according to this invention possess opioid &#x3bc; antagonistic activity and are useful for the treatment or prevention of side effects which are caused by &#x3bc; receptors agonist and which are selected from constipation, nausea/emesis or itch, or for the treatment or prevention of idiopathic constipation, postoperative ileus, paralytic ileus, irritable bowel syndrome or chronic pruritus.

4-(2-furoyl) aminopiperidines, intermediates in synthesizing the same, process for producing the same and medicinal use of the same

Prophylactic and therapeutic agent for hepatic diseases

There is disclosed a multidrug resistance inhibitor for overcoming a multidrug resistance of cancer, or an agent for enhancing the activity of anti-cancer agents, which comprises as an active ingredient a compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein n is an integer of 5 to 12,

Multidrug resistance inhibitors

Isoprene derivatives of formula (I) ##STR1## wherein m is an integer of 0 to 3,

Isoprene derivatives

Disclosed are indole derivatives of formula (I) ##STR1## wherein X and Y each independently represent H or --CH.sub.2 CH.sub.2 R; R represents pyridyl or substituted amino of NR.sub.1 R.sub.2 ;

Indole derivatives

Disclosed are indole derivatives of formula (I) ##STR1## wherein X and Y each independently represent H or --CH.sub.2 CH.sub.2 R;

Disclosed are indole derivatives of formula (I) ##STR1## wherein Y represents H, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy or halogen;

Indole derivatives and anti-ulcer compositions thereof

Disclosed is a rhodanine derivative of formula (I). A rhodanine derivative of formula (I) ##STR1## wherein R.sup.1 is hdyrogen, C.sub.1 -C.sub.8 alkyl, carboxyl(C.sub.1 -C.sub.4)alkyl or (C.sub.1 -C.sub.4)alkoxycarbonyl(C.sub.1 -C.sub.4)alkyl;

Rhodanine derivatives and pharmaceutical compositions

Disclosed are a compound of the formula ##STR1## wherein R.sup.1 is C.sub.1 -C.sub.6 alkyl or a group --(CH.sub.2).sub.n COOR.sup.3 in which n is an integer of 1 to 4 and R.sup.3 is hydrogen or C.sub.1 -C.sub.6 alkyl, and R.sup.2 is a group --CH.dbd.CH--R.sup.4 or --CH.sub.2 --CH.sub.2 --R.sup.4 in which R.sup.4 is substituted or unsubstituted phenyl or a substituted or unsubstituted 5-membered heterocyclic group, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same as an active ingredient. The compounds have an excellent chemical mediator inhibitory activity.

Growing community of inventors

Saitama, Japan

Hitoshi Inoue